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Author | dc.contributor.author | Pastene, Edgar | |
Author | dc.contributor.author | Speisky Cosoy, Hernán | |
Author | dc.contributor.author | García, Apolinaria | |
Author | dc.contributor.author | Moreno, Jessica | |
Author | dc.contributor.author | Troncoso, Miriam | |
Author | dc.contributor.author | Figueroa, Guillermo | |
Admission date | dc.date.accessioned | 2019-03-11T13:00:03Z | |
Available date | dc.date.available | 2019-03-11T13:00:03Z | |
Publication date | dc.date.issued | 2010 | |
Cita de ítem | dc.identifier.citation | Journal of Agricultural and Food Chemistry, Volumen 58, Issue 12, 2018, Pages 7172-7179 | |
Identifier | dc.identifier.issn | 00218561 | |
Identifier | dc.identifier.issn | 15205118 | |
Identifier | dc.identifier.other | 10.1021/jf100274g | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/165012 | |
Abstract | dc.description.abstract | The inhibitory effects of a standarized apple peel polyphenol-rich extract (APPE) against Helicobacter pylori infection and vacuolating bacterial toxin (VacA) induced vacuolation were investigated. Apple peel polyphenols significantly prevented vacuolation in HeLa cells with an IC50 value of 390 μg of gallic acid equivalents (GAE)/mL. APPE also displayed an in vitro antiadhesive effect against H. pylori. A significant inhibition was observed with a 20-60% reduction of H. pylori attachment at concentrations between 0.250 and 5 mg of GAE/mL. In a short-term infection model (C57BL6/J mice), two levels of APPE doses (150 and 300 mg/kg/day) showed an inhibitory effect on H. pylori attachment. Orally administered apple peel polyphenols also showed an anti-inflammatory effect on H. pylori-associated gastritis, lowering malondialdehyde levels and gastritis scores. © 2010 American Chemical Society. | |
Lenguage | dc.language.iso | en | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Journal of Agricultural and Food Chemistry | |
Keywords | dc.subject | Apple peel | |
Keywords | dc.subject | C57BL6/J | |
Keywords | dc.subject | Helicobacter pylori | |
Keywords | dc.subject | Malus domestica | |
Keywords | dc.subject | Polyphenols | |
Keywords | dc.subject | VacA | |
Título | dc.title | In vitro and in vivo effects of apple peel polyphenols against helicobacter pylori | |
Document type | dc.type | Artículo de revista | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile