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27-Hydroxycholesterol induces the transition of MCF7 cells into a mesenchymal phenotype

Authordc.contributor.authorTorres, Cristian G. 
Authordc.contributor.authorRamírez, María Eugenia 
Authordc.contributor.authorCruz, Pamela 
Authordc.contributor.authorEpuñán, María José 
Authordc.contributor.authorValladares Boasi, Luis 
Authordc.contributor.authorSierralta, Walter D. 
Admission datedc.date.accessioned2019-03-11T13:01:43Z
Available datedc.date.available2019-03-11T13:01:43Z
Publication datedc.date.issued2011
Cita de ítemdc.identifier.citationOncology Reports, Volumen 26, Issue 2, 2018, Pages 389-397
Identifierdc.identifier.issn1021335X
Identifierdc.identifier.issn17912431
Identifierdc.identifier.other10.3892/or.2011.1284
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/165257
Abstractdc.description.abstractA decrease in the expression of E-cadherin and β-catenin, paralleling the loss of adherens junction complex, was observed in MCF7 cells exposed for longer than 48 h to 2 μM27-hydroxycholesterol (27OHC), indicating an epithelial-mesenchymal transition (EMT). Upon removal of 27OHC from the culture medium, the cells released by the exposure of 72 h to the oxysterol grew as loosely packed cell groups. In these cells, accumulation of E-cadherin and β-catenin in the cytoplasm and the prolonged expression of epidermal growth factor receptor 2 (EGFR2/neu) in the plasma membrane were observed, suggesting that the acquired phenotype was related to the expression of this tyrosine kinase-growth factor receptor. The results presented here are discussed on the basis of the claimed relationship between 27OHC, hypercholesterolemia, macrophage infiltration and therapy-resistant ERα + breast cancer incidence.
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceOncology Reports
Keywordsdc.subjectβ-catenin
Keywordsdc.subject27-hydroxycholesterol
Keywordsdc.subjectAdherens junction
Keywordsdc.subjectE-cadherin
Keywordsdc.subjectEpidermal growth factor receptor 2/neu
Keywordsdc.subjectHuman mammary cancer
Keywordsdc.subjectMCF7 cells
Títulodc.title27-Hydroxycholesterol induces the transition of MCF7 cells into a mesenchymal phenotype
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile