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Increased expression of the transient receptor potential melastatin 7 channel is critically involved in lipopolysaccharide-induced reactive oxygen species-mediated neuronal death

Authordc.contributor.authorNúñez-Villena, Felipe 
Authordc.contributor.authorBecerra, Alvaro 
Authordc.contributor.authorEcheverría, Cesar 
Authordc.contributor.authorBriceño, Nicolás 
Authordc.contributor.authorPorras, Omar 
Authordc.contributor.authorArmisen Yáñez, Ricardo 
Authordc.contributor.authorVarela, Diego 
Authordc.contributor.authorMontorfano, Ignacio 
Authordc.contributor.authorSarmiento, Daniela 
Authordc.contributor.authorSimon, Felipe 
Admission datedc.date.accessioned2019-03-11T13:01:50Z
Available datedc.date.available2019-03-11T13:01:50Z
Publication datedc.date.issued2011
Cita de ítemdc.identifier.citationAntioxidants and Redox Signaling, Volumen 15, Issue 9, 2018, Pages 2425-2438
Identifierdc.identifier.issn15230864
Identifierdc.identifier.issn15577716
Identifierdc.identifier.other10.1089/ars.2010.3825
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/165284
Abstractdc.description.abstractAims: To assess the mechanisms involved in lipopolysaccharide (LPS)-induced neuronal cell death, we examined the cellular consequences of LPS exposure in differentiated PC12 neurons and primary hippocampal neurons. Results: Our data show that LPS is able to induce PC12 neuronal cell death without the participation of glial cells. Neuronal cell death was mediated by an increase in cellular reactive oxygen species (ROS) levels. Considering the prevalent role of specific ion channels in mediating the deleterious effect of ROS, we assessed their contribution to this process. Neurons exposed to LPS showed a significant intracellular Ca 2+ overload, and nonselective cationic channel blockers inhibited LPS-induced neuronal death. In particular, we observed that both LPS and hydrogen peroxide exposure strongly increased the expression of the transient receptor protein melastatin 7 (TRPM7), which is an ion channel directly implicated in neuronal cell death. Further, both LPS-induced TRPM7 overe
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceAntioxidants and Redox Signaling
Keywordsdc.subjectBiochemistry
Keywordsdc.subjectPhysiology
Keywordsdc.subjectMolecular Biology
Keywordsdc.subjectClinical Biochemistry
Keywordsdc.subjectCell Biology
Títulodc.titleIncreased expression of the transient receptor potential melastatin 7 channel is critically involved in lipopolysaccharide-induced reactive oxygen species-mediated neuronal death
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile