Autophagy as a therapeutic target in cardiovascular disease
Author
dc.contributor.author
Nemchenko, Andriy
Author
dc.contributor.author
Chiong Lay, Mario
Author
dc.contributor.author
Turer, Aslan
Author
dc.contributor.author
Lavandero González, Sergio
Author
dc.contributor.author
Hill, Joseph A.
Admission date
dc.date.accessioned
2019-03-11T13:02:22Z
Available date
dc.date.available
2019-03-11T13:02:22Z
Publication date
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2011
Cita de ítem
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Journal of Molecular and Cellular Cardiology, Volumen 51, Issue 4, 2018, Pages 584-593
Identifier
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00222828
Identifier
dc.identifier.issn
10958584
Identifier
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10.1016/j.yjmcc.2011.06.010
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/165334
Abstract
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The epidemic of heart failure continues apace, and development of novel therapies with clinical efficacy has lagged. Now, important insights into the molecular circuitry of cardiovascular autophagy have raised the prospect that this cellular pathway of protein quality control may be a target of clinical relevance. Whereas basal levels of autophagy are required for cell survival, excessive levels - or perhaps distinct forms of autophagic flux - contribute to disease pathogenesis. Our challenge will be to distinguish mechanisms that drive adaptive versus maladaptive autophagy and to manipulate those pathways for therapeutic gain. Recent evidence suggests this may be possible. Here, we review the fundamental biology of autophagy and its role in a variety of forms of cardiovascular disease. We discuss ways in which this evolutionarily conserved catabolic mechanism can be manipulated, discuss studies presently underway in heart disease, and provide our perspective on where this exciting fie