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Autophagy as a therapeutic target in cardiovascular disease

Authordc.contributor.authorNemchenko, Andriy 
Authordc.contributor.authorChiong Lay, Mario 
Authordc.contributor.authorTurer, Aslan 
Authordc.contributor.authorLavandero González, Sergio 
Authordc.contributor.authorHill, Joseph A. 
Admission datedc.date.accessioned2019-03-11T13:02:22Z
Available datedc.date.available2019-03-11T13:02:22Z
Publication datedc.date.issued2011
Cita de ítemdc.identifier.citationJournal of Molecular and Cellular Cardiology, Volumen 51, Issue 4, 2018, Pages 584-593
Identifierdc.identifier.issn00222828
Identifierdc.identifier.issn10958584
Identifierdc.identifier.other10.1016/j.yjmcc.2011.06.010
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/165334
Abstractdc.description.abstractThe epidemic of heart failure continues apace, and development of novel therapies with clinical efficacy has lagged. Now, important insights into the molecular circuitry of cardiovascular autophagy have raised the prospect that this cellular pathway of protein quality control may be a target of clinical relevance. Whereas basal levels of autophagy are required for cell survival, excessive levels - or perhaps distinct forms of autophagic flux - contribute to disease pathogenesis. Our challenge will be to distinguish mechanisms that drive adaptive versus maladaptive autophagy and to manipulate those pathways for therapeutic gain. Recent evidence suggests this may be possible. Here, we review the fundamental biology of autophagy and its role in a variety of forms of cardiovascular disease. We discuss ways in which this evolutionarily conserved catabolic mechanism can be manipulated, discuss studies presently underway in heart disease, and provide our perspective on where this exciting fie
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceJournal of Molecular and Cellular Cardiology
Keywordsdc.subjectAMPK
Keywordsdc.subjectAutophagy
Keywordsdc.subjectCardiac hypertrophy
Keywordsdc.subjectHDAC inhibitors
Keywordsdc.subjectHeart failure
Keywordsdc.subjectHypertrophy
Keywordsdc.subjectIP3
Keywordsdc.subjectMTOR
Keywordsdc.subjectP53
Keywordsdc.subjectPKA
Keywordsdc.subjectPlasticity
Keywordsdc.subjectRemodeling
Títulodc.titleAutophagy as a therapeutic target in cardiovascular disease
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile