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Conversion to everolimus in liver transplant patients with renal dysfunction

Authordc.contributor.authorPérez Pérez, Macarena 
Authordc.contributor.authorSegovia, Carolina 
Authordc.contributor.authorMartínez Castro, Daniel Castro 
Authordc.contributor.authorRoblero, 
Authordc.contributor.authorEstela, 
Admission datedc.date.accessioned2019-03-11T13:02:23Z
Available datedc.date.available2019-03-11T13:02:23Z
Publication datedc.date.issued2011
Cita de ítemdc.identifier.citationTransplantation Proceedings, Volumen 43, Issue 6, 2018, Pages 2307-2310
Identifierdc.identifier.issn00411345
Identifierdc.identifier.issn18732623
Identifierdc.identifier.other10.1016/j.transproceed.2011.06.009
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/165342
Abstractdc.description.abstractCalcineurin inhibitor (CNI) immunosuppressive therapy postliver transplantation (OLT) is important to reduce graft rejection episodes. However, these drugs show important side effects, particularly renal dysfunction (RDF). Changing from CNI to a nonnephrotoxic drug, as mammalian target of rapamycin (mTOR) inhibitor may solve the problem. Our objective was to evaluate renal function (RF) among liver transplant patients initially receiving CNI, among whom the patients with RDF were converted completely or partially to an mTOR inhibitor like everolimus (EVE). We performed a prospective study in liver transplant patients from 2000 to 2009. Creatinine levels and creatinine clearances (Cockroft-Gault) expressed as mean values ± standard deviations were measured pre- and postswitch for comparisons using Wilcoxon nonparametric tests. Six patients were converted fully or partially to EVE. Their mean age at the moment of introducing the new therapy was 52.2 ± 13.6 years (range = 2860). Immunosup
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceTransplantation Proceedings
Keywordsdc.subjectSurgery
Keywordsdc.subjectTransplantation
Títulodc.titleConversion to everolimus in liver transplant patients with renal dysfunction
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile