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Retinoic acid generates regulatory T cells in experimental transplantation

Authordc.contributor.authorMoore, C. 
Authordc.contributor.authorFuentes C., Claudio 
Authordc.contributor.authorSauma Mahaluf, Daniela 
Authordc.contributor.authorMorales, J. 
Authordc.contributor.authorBono Merino, María Rosa 
Authordc.contributor.authorRosemblatt Silber, Mario César 
Authordc.contributor.authorFierro, J. A. 
Admission datedc.date.accessioned2019-03-11T13:02:25Z
Available datedc.date.available2019-03-11T13:02:25Z
Publication datedc.date.issued2011
Cita de ítemdc.identifier.citationTransplantation Proceedings, Volumen 43, Issue 6, 2018, Pages 2334-2337
Identifierdc.identifier.issn00411345
Identifierdc.identifier.issn18732623
Identifierdc.identifier.other10.1016/j.transproceed.2011.06.057
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/165353
Abstractdc.description.abstractRegulatory T cells play a key role to inhibit effector lymphocytes, avoid, autoimmunity, and restrain allogeneic immunity. Retinoic acid is an important cofactor that stimulates the generation and expansion of regulatory T cells. Naive T cells, coincubated with allogeneic antigen-presenting cells and retinoic acid, in conjunction with transforming growth factor (TGF) β and interleukin (IL) 2, generated allogeneic regulatory T cells de novo. These cells were able to inhibit skin rejection in adoptive transfer experiments. The generation of regulatory T cells ex vivo with retinoic acid, TGF-β, and IL-2 represents a new step toward specific regulation of allogeneic immune responses. © 2011 by Elsevier Inc. All rights reserved.
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceTransplantation Proceedings
Keywordsdc.subjectSurgery
Keywordsdc.subjectTransplantation
Títulodc.titleRetinoic acid generates regulatory T cells in experimental transplantation
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile