Neonatal exposure to single doses of estradiol or testosterone programs ovarian follicular development-modified hypothalamic neurotransmitters and causes polycystic ovary during adulthood in the rat
Author
dc.contributor.author
Sotomayor Zárate, Ramón
Author
dc.contributor.author
Tiszavari, Michelle
Author
dc.contributor.author
Cruz, Gonzalo
Author
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Lara Peñaloza, Hernán
Admission date
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2019-03-11T13:02:59Z
Available date
dc.date.available
2019-03-11T13:02:59Z
Publication date
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2011
Cita de ítem
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Fertility and Sterility, Volumen 96, Issue 6, 2018, Pages 1490-1496
Identifier
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00150282
Identifier
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15565653
Identifier
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10.1016/j.fertnstert.2011.09.011
Identifier
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https://repositorio.uchile.cl/handle/2250/165419
Abstract
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Objective: To investigate the hormones participating in early follicular development and hypothalamic neurotransmitters in rats during adulthood. Design: Experimental basic study. Setting: University animal laboratory. Animal(s): Twenty-three neonatal rats injected with single subcutaneous injection of estradiol valerate (EV), testosterone propionate (TP), or dihydrotestosterone (DHT) and killed by decapitation at 60 days of age. Intervention(s): Measurements of neurotransmitter in ventromedial hypothalamus-arcuate nucleus (VMH-AN) and ovarian morphometry in the adult rat. Main Outcome Measure(s): Noradrenaline (NA), dopamine (DA), serotonin (5-HT), glutamic acid (Glu), and gamma-aminobutyric acid (GABA) content by high performance liquid chromatography medial basal hypothalamus and ovarian morphology. Result(s): EV exposure increased 5-HT, DA, NA, and Glu and decreased GABA levels in the VMH-AN. Exposure to TP increased Glu and decreased 5-HT in the VMH-AN. Neonatal EV and TP decrease
Neonatal exposure to single doses of estradiol or testosterone programs ovarian follicular development-modified hypothalamic neurotransmitters and causes polycystic ovary during adulthood in the rat