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Neonatal exposure to single doses of estradiol or testosterone programs ovarian follicular development-modified hypothalamic neurotransmitters and causes polycystic ovary during adulthood in the rat

Authordc.contributor.authorSotomayor Zárate, Ramón 
Authordc.contributor.authorTiszavari, Michelle 
Authordc.contributor.authorCruz, Gonzalo 
Authordc.contributor.authorLara Peñaloza, Hernán 
Admission datedc.date.accessioned2019-03-11T13:02:59Z
Available datedc.date.available2019-03-11T13:02:59Z
Publication datedc.date.issued2011
Cita de ítemdc.identifier.citationFertility and Sterility, Volumen 96, Issue 6, 2018, Pages 1490-1496
Identifierdc.identifier.issn00150282
Identifierdc.identifier.issn15565653
Identifierdc.identifier.other10.1016/j.fertnstert.2011.09.011
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/165419
Abstractdc.description.abstractObjective: To investigate the hormones participating in early follicular development and hypothalamic neurotransmitters in rats during adulthood. Design: Experimental basic study. Setting: University animal laboratory. Animal(s): Twenty-three neonatal rats injected with single subcutaneous injection of estradiol valerate (EV), testosterone propionate (TP), or dihydrotestosterone (DHT) and killed by decapitation at 60 days of age. Intervention(s): Measurements of neurotransmitter in ventromedial hypothalamus-arcuate nucleus (VMH-AN) and ovarian morphometry in the adult rat. Main Outcome Measure(s): Noradrenaline (NA), dopamine (DA), serotonin (5-HT), glutamic acid (Glu), and gamma-aminobutyric acid (GABA) content by high performance liquid chromatography medial basal hypothalamus and ovarian morphology. Result(s): EV exposure increased 5-HT, DA, NA, and Glu and decreased GABA levels in the VMH-AN. Exposure to TP increased Glu and decreased 5-HT in the VMH-AN. Neonatal EV and TP decrease
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceFertility and Sterility
Keywordsdc.subjectEstradiol
Keywordsdc.subjectfollicular development
Keywordsdc.subjectneonatal programming
Keywordsdc.subjectovary
Keywordsdc.subjecttestosterone
Títulodc.titleNeonatal exposure to single doses of estradiol or testosterone programs ovarian follicular development-modified hypothalamic neurotransmitters and causes polycystic ovary during adulthood in the rat
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile