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Authordc.contributor.authorZamorano, Sebastián 
Authordc.contributor.authorRojas Rivera, Diego 
Authordc.contributor.authorLisbona, Fernanda 
Authordc.contributor.authorParra, Valentina 
Authordc.contributor.authorCourt, Felipe A. 
Authordc.contributor.authorVillegas, Rosario 
Authordc.contributor.authorCheng, Emily H. 
Authordc.contributor.authorKorsmeyer, Stanley J. 
Authordc.contributor.authorLavandero González, Sergio 
Authordc.contributor.authorHetz Flores, Claudio 
Admission datedc.date.accessioned2019-03-11T13:03:59Z
Available datedc.date.available2019-03-11T13:03:59Z
Publication datedc.date.issued2012
Cita de ítemdc.identifier.citationPLoS ONE, Volumen 7, Issue 6, 2018,
Identifierdc.identifier.issn19326203
Identifierdc.identifier.other10.1371/journal.pone.0037782
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/165582
Abstractdc.description.abstractMost intrinsic death signals converge into the activation of pro-apoptotic BCL-2 family members BAX and BAK at the mitochondria, resulting in the release of cytochrome c and apoptosome activation. Chronic endoplasmic reticulum (ER) stress leads to apoptosis through the upregulation of a subset of pro-apoptotic BH3-only proteins, activating BAX and BAK at the mitochondria. Here we provide evidence indicating that the full resistance of BAX and BAK double deficient (DKO) cells to ER stress is reverted by stimulation in combination with mild serum withdrawal. Cell death under these conditions was characterized by the appearance of classical apoptosis markers, caspase-9 activation, release of cytochrome c, and was inhibited by knocking down caspase-9, but insensitive to BCL-XL overexpression. Similarly, the resistance of BIM and PUMA double deficient cells to ER stress was reverted by mild serum withdrawal. Surprisingly, BAX/BAK-independent cell death did not require Cyclophilin D (CypD) e
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourcePLoS ONE
Keywordsdc.subjectBiochemistry, Genetics and Molecular Biology (all)
Keywordsdc.subjectAgricultural and Biological Sciences (all)
Títulodc.titleA BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile