Singlet oxygen reactions with flavonoids. a theoretical - experimental study
Author
dc.contributor.author
Morales, Javier
Author
dc.contributor.author
Günther, Germán
Author
dc.contributor.author
Zanocco, Antonio L.
Author
dc.contributor.author
Lemp, Else
Admission date
dc.date.accessioned
2019-03-11T13:19:27Z
Available date
dc.date.available
2019-03-11T13:19:27Z
Publication date
dc.date.issued
2012
Cita de ítem
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PLoS ONE, Volumen 7, Issue 7, 2018,
Identifier
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19326203
Identifier
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10.1371/journal.pone.0040548
Identifier
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https://repositorio.uchile.cl/handle/2250/165610
Abstract
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Detection of singlet oxygen emission, λmax = 1270 nm, following laser excitation and steady-state methods were employed to measure the total reaction rate constant, kT, and the reactive reaction rate constant, kr, for the reaction between singlet oxygen and several flavonoids. Values of kT determined in deuterated water, ranging from 2.4×107 M-1s-1 to 13.4×107 M-1s-1, for rutin and morin, respectively, and the values measured for kr, ranging from 2.8×105 M-1s-1 to 65.7×105 M-1s-1 for kaempferol and morin, respectively, being epicatechin and catechin chemically unreactive. These results indicate that all the studied flavonoids are good quenchers of singlet oxygen and could be valuable antioxidants in systems under oxidative stress, in particular if a flavonoid-rich diet was previously consumed. Analysis of the dependence of rate constant values with molecular structure in terms of global descriptors and condensed Fukui functions, resulting from electronic structure calculations, support