Show simple item record

Authordc.contributor.authorMardones, Marcelo 
Authordc.contributor.authorValenzuela, Rodrigo 
Authordc.contributor.authorRomanque, Pamela 
Authordc.contributor.authorCovarrubias, Natalia 
Authordc.contributor.authorAnghileri, Fiorella 
Authordc.contributor.authorFernández Arancibia, Virginia 
Authordc.contributor.authorVidela Cabrera, Luis 
Authordc.contributor.authorTapia Opazo, Gladys 
Admission datedc.date.accessioned2019-03-11T13:19:27Z
Available datedc.date.available2019-03-11T13:19:27Z
Publication datedc.date.issued2012
Cita de ítemdc.identifier.citationJournal of Nutritional Biochemistry, Volumen 23, Issue 9, 2018, Pages 1113-1120
Identifierdc.identifier.issn09552863
Identifierdc.identifier.issn18734847
Identifierdc.identifier.other10.1016/j.jnutbio.2011.06.004
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/165612
Abstractdc.description.abstractSeveral preconditioning strategies are used to prevent ischemia-reperfusion (IR) liver injury, a deleterious condition associated with tissue resection, transplantation or trauma. Although thyroid hormone (T3) administration exerts significant protection against liver IR injury in the rat, its clinical application is controversial due to possible adverse effects. Considering that prevention of liver IR injury has also been achieved by n-3 polyunsaturated fatty acid (n-3 PUFA) supplementation to rats, we studied the effect of n-3 PUFA dietary supplementation plus a lower dose of T3 against IR injury. Male Sprague-Dawley rats receiving fish oil (300 mg/kg) for 3 days followed by a single intraperitoneal dose of 0.05 mg T3/kg were subjected to 1 h of ischemia followed by 20 h of reperfusion. Parameters of liver injury (serum transaminases, histology) and oxidative stress (liver contents of GSH and oxidized proteins) were correlated with fatty acid composition, NF-κB activity, and tumor ne
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceJournal of Nutritional Biochemistry
Keywordsdc.subjectFish oil supplementation
Keywordsdc.subjectIschemia-reperfusion injury
Keywordsdc.subjectLiver preconditioning
Keywordsdc.subjectN-3 PUFA
Keywordsdc.subjectNF-κB activity
Keywordsdc.subjectOxidative stress
Keywordsdc.subjectThyroid hormone
Títulodc.titlePrevention of liver ischemia reperfusion injury by a combined thyroid hormone and fish oil protocol
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


Files in this item

Icon

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile