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Nerve growth factor stimulates cellular proliferation of human epithelial ovarian cancer

Authordc.contributor.authorUrzua, U. 
Authordc.contributor.authorTapia, V. 
Authordc.contributor.authorGeraldo, M. P. 
Authordc.contributor.authorSelman, A. 
Authordc.contributor.authorVega, M. 
Authordc.contributor.authorRomero, C. 
Admission datedc.date.accessioned2019-03-11T13:19:33Z
Available datedc.date.available2019-03-11T13:19:33Z
Publication datedc.date.issued2012
Cita de ítemdc.identifier.citationHormone and Metabolic Research, Volumen 44, Issue 9, 2018, Pages 656-661
Identifierdc.identifier.issn00185043
Identifierdc.identifier.issn14394286
Identifierdc.identifier.other10.1055/s-0032-1304617
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/165653
Abstractdc.description.abstractDue to its ability to induce vascular endothelial growth factor expression and proliferation, migration, and vasculogenesis of endothelial cells, nerve growth factor (NGF) has been considered as an angiogenic factor in epithelial ovarian cancer (EOC). In this work, we evaluated the angiogenic and proliferative mRNA expression profiles of EOC and addressed the responsiveness of EOC explants to NGF stimulation. Twenty EOC samples were obtained from Obstetrics and Gynecology Department, University of Chile's Clinical Hospital. Global gene expression profiles of selected poorly differentiated serous EOC samples were obtained with DNA oligonucleotide microarrays. In addition, EOC explants were subjected to NGF stimulation and levels of p-AKT, BAX, BCL2, Ki-67, c-MYC, and FOXL2 proteins were determined by immunohistochemistry. Results showed that mRNAs coding for specific transcriptional regulators and antiapoptotic components of the NGF signaling pathway were upregulated in EOC cells. At th
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceHormone and Metabolic Research
Keywordsdc.subjectEOC
Keywordsdc.subjectHOSE
Keywordsdc.subjectNGF
Keywordsdc.subjectproliferation
Títulodc.titleNerve growth factor stimulates cellular proliferation of human epithelial ovarian cancer
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile