C-reactive protein levels in patients with chronic obstructive pulmonary disease Proteína C reactiva en la EPOC y su relación con la gravedad de la enfermedad, las exacerbaciones y las comorbilidades
Author
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Díaz, Orlando
Author
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Parada, Alejandra
Author
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Ramos, Cristóbal
Author
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Klaassen, Julieta
Author
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Díaz, Juan Carlos
Author
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Andresen, Max
Author
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Lisboa, Carmen
Author
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Saldías, Fernando
Admission date
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2019-03-11T13:19:40Z
Available date
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2019-03-11T13:19:40Z
Publication date
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2012
Cita de ítem
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Revista Medica de Chile, Volumen 140, Issue 5, 2018, Pages 569-578
Identifier
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00349887
Identifier
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07176163
Identifier
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10.4067/S0034-98872012000500003
Identifier
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https://repositorio.uchile.cl/handle/2250/165699
Abstract
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Background: Patients with chronic obstructive pulmonary disease (COPD) have elevated serum levels of ultrasensitive C reactive protein (CRPus). This raise may be related directly to COPD and its associated systemic inflammation or secondary to other factors such as smoking status, disease severity, acute exacerbations, or associated complications. Aim: To evaluate the potential causes of raised levels of CRPus in stable COPD patients. Patients and Methods: Cohorts of 133 mild-to-very severe COPD patients (41 current smokers), 31 never-smokers, and 33 current smoker controls were compared. Clinical assessments included body mass index (BMI), fat (FM) and fat-free mass (FFM) measurement by DEXA, forced expiratory volume in one second (FEV1), arterial oxygen tension (PaO2), six-minute walking test (SMWT), emphysema (EMPH) and right thigh muscle cross-sectional area (TMCSA), both quantified by high resolution computed tomography. Results: Serum CRPus levels were significantly higher in COP
C-reactive protein levels in patients with chronic obstructive pulmonary disease Proteína C reactiva en la EPOC y su relación con la gravedad de la enfermedad, las exacerbaciones y las comorbilidades