Evidence for a celiac ganglion-ovarian kisspeptin neural network in the rat: Intraovarian anti-kisspeptin delays vaginal opening and alters estrous cyclicity
Kisspeptin and its receptor GPR54 have been described as key hypothalamic components in the regulation of GnRH secretion. Kisspeptin is also present in several regions of the central nervous system and the peripheral organs and has recently been identified in the superior ganglion. Herein, wetested the possibility that ovarian kisspeptin is regulated by the sympathetic nervous systemand participates locally in the regulation of ovarian function. Both ovarian and celiac ganglion kisspeptin mRNA levels increase during development, whereas kisspeptin peptide levels and plasma levels decrease during development. In the celiac ganglion, kisspeptin colocalized with tyrosine hydroxylase, indicating potential kisspeptin synthesis and transport within the sympathetic neurons. A continuous (64 h) cold stress induced marked changes within the kisspeptin neural system along the celiac ganglion-ovary axis. In vitro incubation with the β-adrenergic agonist isoproterenol increased ovarian kisspeptin
Evidence for a celiac ganglion-ovarian kisspeptin neural network in the rat: Intraovarian anti-kisspeptin delays vaginal opening and alters estrous cyclicity