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Protein carbonylation and adipocyte mitochondrial function
Autor | dc.contributor.author | Curtis, Jessica M. | |
Autor | dc.contributor.author | Hahn, Wendy S. | |
Autor | dc.contributor.author | Stone, Matthew D. | |
Autor | dc.contributor.author | Inda, Jacob J. | |
Autor | dc.contributor.author | Droullard, David J. | |
Autor | dc.contributor.author | Kuzmicic, Jovan P. | |
Autor | dc.contributor.author | Donoghue, Margaret A. | |
Autor | dc.contributor.author | Long, Eric K. | |
Autor | dc.contributor.author | Armien, Anibal G. | |
Autor | dc.contributor.author | Lavandero González, Sergio | |
Autor | dc.contributor.author | Arriaga, Edgar | |
Autor | dc.contributor.author | Griffin, Timothy J. | |
Autor | dc.contributor.author | Bernlohr, David A. | |
Fecha ingreso | dc.date.accessioned | 2019-03-15T16:03:27Z | |
Fecha disponible | dc.date.available | 2019-03-15T16:03:27Z | |
Fecha de publicación | dc.date.issued | 2012 | |
Cita de ítem | dc.identifier.citation | Journal of Biological Chemistry, Volumen 287, Issue 39, 2018, Pages 32967-32980 | |
Identificador | dc.identifier.issn | 00219258 | |
Identificador | dc.identifier.issn | 1083351X | |
Identificador | dc.identifier.other | 10.1074/jbc.M112.400663 | |
Identificador | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/165837 | |
Resumen | dc.description.abstract | Carbonylation is the covalent, non-reversible modification of the side chains of cysteine, histidine, and lysine residues by lipid peroxidation end products such as 4-hydroxy- and 4-oxononenal. In adipose tissue the effects of such modifications are associated with increased oxidative stress and metabolic dysregulation centered on mitochondrial energy metabolism. To address the role of protein carbonylation in the pathogenesis of mitochondrial dysfunction, quantitative proteomics was employed to identify specific targets of carbonylation in GSTA4-silenced or overexpressing 3T3-L1 adipocytes. GSTA4-silenced adipocytes displayed elevated carbonylation of several key mitochondrial proteins including the phosphate carrier protein, NADH dehydrogenase 1α subcomplexes 2 and 3, translocase of inner mitochondrial membrane 50, and valyl-tRNA synthetase. Elevated protein carbonylation is accompanied by diminished complex I activity, impaired respiration, increased superoxide production, and a red | |
Idioma | dc.language.iso | en | |
Tipo de licencia | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link a Licencia | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Fuente | dc.source | Journal of Biological Chemistry | |
Palabras claves | dc.subject | Biochemistry | |
Palabras claves | dc.subject | Molecular Biology | |
Palabras claves | dc.subject | Cell Biology | |
Título | dc.title | Protein carbonylation and adipocyte mitochondrial function | |
Tipo de documento | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso Abierto | |
Catalogador | uchile.catalogador | SCOPUS | |
Indización | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI |
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