Show simple item record

Protein carbonylation and adipocyte mitochondrial function

Authordc.contributor.authorCurtis, Jessica M. 
Authordc.contributor.authorHahn, Wendy S. 
Authordc.contributor.authorStone, Matthew D. 
Authordc.contributor.authorInda, Jacob J. 
Authordc.contributor.authorDroullard, David J. 
Authordc.contributor.authorKuzmicic, Jovan P. 
Authordc.contributor.authorDonoghue, Margaret A. 
Authordc.contributor.authorLong, Eric K. 
Authordc.contributor.authorArmien, Anibal G. 
Authordc.contributor.authorLavandero González, Sergio 
Authordc.contributor.authorArriaga, Edgar 
Authordc.contributor.authorGriffin, Timothy J. 
Authordc.contributor.authorBernlohr, David A. 
Admission datedc.date.accessioned2019-03-15T16:03:27Z
Available datedc.date.available2019-03-15T16:03:27Z
Publication datedc.date.issued2012
Cita de ítemdc.identifier.citationJournal of Biological Chemistry, Volumen 287, Issue 39, 2018, Pages 32967-32980
Identifierdc.identifier.issn00219258
Identifierdc.identifier.issn1083351X
Identifierdc.identifier.other10.1074/jbc.M112.400663
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/165837
Abstractdc.description.abstractCarbonylation is the covalent, non-reversible modification of the side chains of cysteine, histidine, and lysine residues by lipid peroxidation end products such as 4-hydroxy- and 4-oxononenal. In adipose tissue the effects of such modifications are associated with increased oxidative stress and metabolic dysregulation centered on mitochondrial energy metabolism. To address the role of protein carbonylation in the pathogenesis of mitochondrial dysfunction, quantitative proteomics was employed to identify specific targets of carbonylation in GSTA4-silenced or overexpressing 3T3-L1 adipocytes. GSTA4-silenced adipocytes displayed elevated carbonylation of several key mitochondrial proteins including the phosphate carrier protein, NADH dehydrogenase 1α subcomplexes 2 and 3, translocase of inner mitochondrial membrane 50, and valyl-tRNA synthetase. Elevated protein carbonylation is accompanied by diminished complex I activity, impaired respiration, increased superoxide production, and a red
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceJournal of Biological Chemistry
Keywordsdc.subjectBiochemistry
Keywordsdc.subjectMolecular Biology
Keywordsdc.subjectCell Biology
Títulodc.titleProtein carbonylation and adipocyte mitochondrial function
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


Files in this item

Icon

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile