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Authordc.contributor.authorCurtis, Jessica M. 
Authordc.contributor.authorHahn, Wendy S. 
Authordc.contributor.authorStone, Matthew D. 
Authordc.contributor.authorInda, Jacob J. 
Authordc.contributor.authorDroullard, David J. 
Authordc.contributor.authorKuzmicic, Jovan P. 
Authordc.contributor.authorDonoghue, Margaret A. 
Authordc.contributor.authorLong, Eric K. 
Authordc.contributor.authorArmien, Anibal G. 
Authordc.contributor.authorLavandero González, Sergio 
Authordc.contributor.authorArriaga, Edgar 
Authordc.contributor.authorGriffin, Timothy J. 
Authordc.contributor.authorBernlohr, David A. 
Cita de ítemdc.identifier.citationJournal of Biological Chemistry, Volumen 287, Issue 39, 2018, Pages 32967-32980
Abstractdc.description.abstractCarbonylation is the covalent, non-reversible modification of the side chains of cysteine, histidine, and lysine residues by lipid peroxidation end products such as 4-hydroxy- and 4-oxononenal. In adipose tissue the effects of such modifications are associated with increased oxidative stress and metabolic dysregulation centered on mitochondrial energy metabolism. To address the role of protein carbonylation in the pathogenesis of mitochondrial dysfunction, quantitative proteomics was employed to identify specific targets of carbonylation in GSTA4-silenced or overexpressing 3T3-L1 adipocytes. GSTA4-silenced adipocytes displayed elevated carbonylation of several key mitochondrial proteins including the phosphate carrier protein, NADH dehydrogenase 1α subcomplexes 2 and 3, translocase of inner mitochondrial membrane 50, and valyl-tRNA synthetase. Elevated protein carbonylation is accompanied by diminished complex I activity, impaired respiration, increased superoxide production, and a red
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceJournal of Biological Chemistry
Keywordsdc.subjectMolecular Biology
Keywordsdc.subjectCell Biology
Títulodc.titleProtein carbonylation and adipocyte mitochondrial function
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile