Steroid withdrawal in pediatric kidney transplant allows better growth, lipids and body composition: A randomized controlled trial
Author
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Mericq, Verónica
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Salas, Paulina
Author
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Pinto, Viola
Author
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Cano Schuffeneger, Francisco
Author
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Reyes, Loreto
Author
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Brown, Keenan
Author
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Gonzalez, Magdalena
Author
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Michea Acevedo, Luis
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Delgado, Iris
Author
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Delucchi Bicocchi, María Angela
Admission date
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2019-03-15T16:04:23Z
Available date
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2019-03-15T16:04:23Z
Publication date
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2013
Cita de ítem
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Hormone Research in Paediatrics, Volumen 79, Issue 2, 2018, Pages 88-96
Identifier
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16632818
Identifier
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16632826
Identifier
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10.1159/000347024
Identifier
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https://repositorio.uchile.cl/handle/2250/165956
Abstract
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Background: Glucocorticoid immunosuppressant therapy in pediatric kidney transplant (Tx) recipients does not allow the improvement of growth after Tx. Objective: To determine the effect of early steroid withdrawal (SW) on longitudinal growth, insulin sensitivity (IS), and body composition (BC). Methods: This was a prospective, randomized, multicenter study in Tx. Insulin-like growth factor (IGF)-I, IGF-binding protein 3 (IGFBP3), IS, and BC (DEXA/pQCT) were determined at baseline and up to 12 months after Tx. Results: A total of 30 patients were examined; 14 patients were assigned to the SW group (7 male, 7 female; 12 in Tanner stage I) and 16 patients were assigned to the steroid control (SC) group (10 male, 6 female;12 in Tanner stage I). Their chronological age was 7.8 ± 4.3 years, height was -2.3 ± 0.99 SD scores (SDS), and body mass index -0.3 ± 1.2 SDS. After 1 year, the SW group showed an increase in height SDS (+1.2 ± 0.22 vs. +0.60 ± 0.13 SDS in the SC group, p < 0.02), lower