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Microstructural brain and multivoxel spectroscopy in very low birth weight infants related to insulin-like growth factor concentration and early growth

Authordc.contributor.authorOkuma, Cecilia 
Authordc.contributor.authorHernández, M. Isabel 
Authordc.contributor.authorRodríguez, Pablo 
Authordc.contributor.authorPorras Flores, Rodrigo Antonio 
Authordc.contributor.authorAvila, Alejandra 
Authordc.contributor.authorCavada Chacón, Gabriel 
Authordc.contributor.authorKopplin, Erika 
Authordc.contributor.authorRossel, Katherine 
Authordc.contributor.authorIñíguez Vila, Germán 
Authordc.contributor.authorMericq, Verónica 
Cita de ítemdc.identifier.citationHormone Research in Paediatrics, Volumen 79, Issue 4, 2018, Pages 197-207
Abstractdc.description.abstractBackground: Very low birth weight (VLBW) children have higher risk of neurologic disabilities and growth factors are essential for brain maturation. Aim: To assess whether there are differences in neurologic findings, psychometric parameters and microstructural brain morphology in 1-year-old VLBW infants versus term healthy controls and whether these differences are related to hormonal/growth changes. Methods: Prospective anthropometry, prefeed venous blood sample [insulin, insulin-like growth factor-I (IGF-I), insulin-like growth factor-II (IGF-II), leptin, glucose], neurologic and imaging assessment, at age 1 year in 34 VLBW infants (12 SGA; 10 M) and 10 healthy term controls (5 M). Results: IGF-I concentrations at 1 month of corrected age were 20% lower in SGA versus appropriate for gestational age VLBW (p < 0.02). Gray and white matter volume and fractional anisotropy in 15/27 regions were decreased (p < 0.001). Abnormal spectroscopy was observed in 4 zones in VLBW versus term cont
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceHormone Research in Paediatrics
Keywordsdc.subjectBrain maturation
Keywordsdc.subjectGrowth and growth factors
Títulodc.titleMicrostructural brain and multivoxel spectroscopy in very low birth weight infants related to insulin-like growth factor concentration and early growth
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile