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Author | dc.contributor.author | Echeverría, Cesar | |
Author | dc.contributor.author | Montorfano, Ignacio | |
Author | dc.contributor.author | Cabello Verrugio, Claudio | |
Author | dc.contributor.author | Armisén, Ricardo | |
Author | dc.contributor.author | Varela, Diego | |
Author | dc.contributor.author | Simon, Felipe | |
Admission date | dc.date.accessioned | 2019-03-18T11:52:57Z | |
Available date | dc.date.available | 2019-03-18T11:52:57Z | |
Publication date | dc.date.issued | 2015 | |
Cita de ítem | dc.identifier.citation | Journal of Hypertension, Volumen 33, Issue 5, 2018, Pages 981-992 | |
Identifier | dc.identifier.issn | 14735598 | |
Identifier | dc.identifier.issn | 02636352 | |
Identifier | dc.identifier.other | 10.1097/HJH.0000000000000496 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/166556 | |
Abstract | dc.description.abstract | © 2015 Wolters Kluwer Health | Lippincott Williams & Wilkins.Objective: To study whether transient receptor potential melastatin 4 (TRPM4) participates in endothelial fibrosis and to investigate the underlying mechanism. Methods: Primary human endothelial cells were used and pharmacological and short interfering RNA-based approaches were used to test the transforming growth factor beta (TGF-β)/activin receptor-like kinase 5 (ALK5) pathway participation and contribution of TRPM7 ion channel. Results: Suppression of TRPM4 expression leads to decreased endothelial protein expression and increased expression of fibrotic and extracellular matrix markers. Furthermore, TRPM4 downregulation increases intracellular Ca<sup>2+</sup> levels as a potential condition for fibrosis. The underlying mechanism of endothelial fibrosis shows that inhibition of TRPM4 expression induces TGF-β1 and TGF-β2 expression, which act through their receptor, ALK5, and the nuclear translocation of the profibrotic tran | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | Lippincott Williams and Wilkins | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Journal of Hypertension | |
Keywords | dc.subject | Endothelial dysfunction | |
Keywords | dc.subject | Fibrosis | |
Keywords | dc.subject | Inflammation | |
Keywords | dc.subject | TGF-β | |
Keywords | dc.subject | TRPM4 | |
Título | dc.title | Suppression of transient receptor potential melastatin 4 expression promotes conversion of endothelial cells into fibroblasts via transforming growth factor/activin receptor-like kinase 5 pathway | |
Document type | dc.type | Artículo de revista | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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