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Author dc.contributor.author Carrasco Pozo, Catalina
Author dc.contributor.author Gotteland, Martin
Author dc.contributor.author Castillo, Rodrigo L.
Author dc.contributor.author Chen, Chen
Admission date dc.date.accessioned 2019-03-18T11:52:58Z
Available date dc.date.available 2019-03-18T11:52:58Z
Publication date dc.date.issued 2015
Cita de ítem dc.identifier.citation Experimental Cell Research, Volumen 334, Issue 2, 2018, Pages 270-282
Identifier dc.identifier.issn 10902422
Identifier dc.identifier.issn 00144827
Identifier dc.identifier.other 10.1016/j.yexcr.2015.03.021
Identifier dc.identifier.uri https://repositorio.uchile.cl/handle/2250/166562
Abstract dc.description.abstract © 2015 Elsevier Inc. Cholesterol plays an important role in inducing pancreatic β-cell dysfunction, characterized by an impaired insulin secretory response to glucose, representing a hallmark of the transition from pre-diabetes to diabetes. 3,4 dihydroxyphenylacetic acid (ES) is a scarcely studied microbiota-derived metabolite of quercetin with antioxidant properties. The aim of this study was to determine the protective effect of ES against apoptosis, mitochondrial dysfunction and oxidative stress induced by cholesterol in Min6 pancreatic β-cells. Cholesterol decreased viability, induced apoptosis and mitochondrial dysfunction by reducing complex I activity, mitochondrial membrane potential, ATP levels and oxygen consumption. Cholesterol promoted oxidative stress by increasing cellular and mitochondrial reactive oxygen species and lipid peroxidation and decreasing antioxidant enzyme activities; in addition, it slightly increased Nrf2 translocation to the nucleus. These events resulted
Lenguage dc.language.iso en
Publisher dc.publisher Academic Press Inc.
Type of license dc.rights Attribution-NonCommercial-NoDerivs 3.0 Chile
Link to License dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Source dc.source Experimental Cell Research
Keywords dc.subject 3,4 dihydroxyphenylacetic acid
Keywords dc.subject ATP
Keywords dc.subject Cholesterol
Keywords dc.subject Insulin secretion
Keywords dc.subject Mitochondrial dysfunction
Keywords dc.subject Pancreatic β-cell
Keywords dc.subject Superoxide anion radicals
Título dc.title 3,4-dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, protects against pancreatic β-cells dysfunction induced by high cholesterol
Document type dc.type Artículo de revista
Cataloguer uchile.catalogador SCOPUS
Indexation uchile.index Artículo de publicación SCOPUS
uchile.cosecha uchile.cosecha SI
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