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Anti-Apoptotic effects of 3,3',5-triiodo-lthyronine in the liver of brain-dead rats

Authordc.contributor.authorRebolledo, Rolando A. 
Authordc.contributor.authorVan Erp, Anne C. 
Authordc.contributor.authorOttens, Petra J. 
Authordc.contributor.authorWiersema-Buist, Janneke 
Authordc.contributor.authorLeuvenink, Henri G. D. 
Authordc.contributor.authorRomanque, Pamela 
Admission datedc.date.accessioned2019-03-18T11:53:39Z
Available datedc.date.available2019-03-18T11:53:39Z
Publication datedc.date.issued2015
Cita de ítemdc.identifier.citationPLoS ONE, Volumen 10, Issue 10, 2018,
Identifierdc.identifier.issn19326203
Identifierdc.identifier.other10.1371/journal.pone.0138749
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/166691
Abstractdc.description.abstract© 2015 Rebolledo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Background Thyroid hormone treatment in brain-dead organ donors has been extensively studied and applied in the clinical setting. However, its clinical applicability remains controversial due to a varying degree of success and a lack of mechanistic understanding about the therapeutic effects of 3,3',5-Triiodo-L-thyronine (T3). T3 pre-conditioning leads to anti-Apoptotic and promitotic effects in liver tissue following ischemia/reperfusion injury. Therefore, we aimed to study the effects of T3 pre-conditioning in the liver of brain-dead rats. Methods Brain death (BD) was induced in mechanically ventilated rats by inflation of a Fogarty catheter in the epidural space. T3 (0.1 mg/kg) or vehicle was administered intraperitoneally 2 h p
Lenguagedc.language.isoen
Publisherdc.publisherPublic Library of Science
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourcePLoS ONE
Keywordsdc.subjectBiochemistry, Genetics and Molecular Biology (all)
Keywordsdc.subjectAgricultural and Biological Sciences (all)
Títulodc.titleAnti-Apoptotic effects of 3,3',5-triiodo-lthyronine in the liver of brain-dead rats
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile