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Author | dc.contributor.author | Serrano, Carolina A. | |
Author | dc.contributor.author | Villagrán, Andrea | |
Author | dc.contributor.author | Toledo, Héctor | |
Author | dc.contributor.author | Crabtree, Jean E. | |
Author | dc.contributor.author | Harris, Paul R. | |
Admission date | dc.date.accessioned | 2019-03-18T11:53:48Z | |
Available date | dc.date.available | 2019-03-18T11:53:48Z | |
Publication date | dc.date.issued | 2016 | |
Cita de ítem | dc.identifier.citation | Helicobacter, Volumen 21, Issue 2, 2018, Pages 124-130 | |
Identifier | dc.identifier.issn | 15235378 | |
Identifier | dc.identifier.issn | 10834389 | |
Identifier | dc.identifier.other | 10.1111/hel.12247 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/166744 | |
Abstract | dc.description.abstract | © 2016 John Wiley & Sons Ltd.Background: Helicobacter pylori infection has been associated with an imbalance of iron homeostasis. IL-1β has been related with iron absorption disturbances through a variety of mechanisms. The aim of this study was to evaluate the presence of polymorphic variants for IL-1β cluster and gastric IL1β mRNA expression in H. pylori-infected children and their relationship with hypochlorhydria and iron deficiency (ID). Patients and Methods: Prospective study of 123 symptomatic children. At endoscopy, antral biopsies were taken for urease test, pathology and culture and blood for analysis of ferritin, transferrin, serum iron, and total iron-binding capacity. Polymorphisms in the IL-1β cluster (positions -511, -31, +3954, ILRN) were determined by PCR-RFLP. Gastric mucosal expression of IL-1β mRNA was determined by RT-PCR. Results: After exclusions, of 105 patients, 33 (31.4%) were H. pylori positive. Nine (8.6%) children were classified as iron deficient (ID). Hel | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | Blackwell Publishing Ltd | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Helicobacter | |
Keywords | dc.subject | Children | |
Keywords | dc.subject | Helicobacter pylori | |
Keywords | dc.subject | Interleukin-1β polymorphisms | |
Keywords | dc.subject | Iron deficiency | |
Título | dc.title | Iron Deficiency and IL1β Polymorphisms in Helicobacter pylori-infected Children | |
Document type | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso Abierto | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile