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Humoral and intestinal immunity induced by new schedules of bivalent oral poliovirus vaccine and one or two doses of inactivated poliovirus vaccine in Latin American infants: an open-label randomised controlled trial

Authordc.contributor.authorAsturias, Edwin J. 
Authordc.contributor.authorBandyopadhyay, Ananda S. 
Authordc.contributor.authorSelf, Steve 
Authordc.contributor.authorRivera, Luis 
Authordc.contributor.authorSáez Llorens, Xavier 
Authordc.contributor.authorLopez, Eduardo 
Authordc.contributor.authorMelgar, Mario 
Authordc.contributor.authorGaensbauer, James T. 
Authordc.contributor.authorWeldon, William C. 
Authordc.contributor.authorOberste, M. Steven 
Authordc.contributor.authorBorate, Bhavesh R. 
Authordc.contributor.authorGast, Chris 
Authordc.contributor.authorClemens, Ralf 
Authordc.contributor.authorOrenstein, Walter 
Authordc.contributor.authorO'Ryan Gallardo, Miguel 
Admission datedc.date.accessioned2019-03-18T11:54:18Z
Available datedc.date.available2019-03-18T11:54:18Z
Publication datedc.date.issued2016
Cita de ítemdc.identifier.citationThe Lancet, Volumen 388, Issue 10040, 2018, Pages 158-169
Identifierdc.identifier.issn1474547X
Identifierdc.identifier.issn01406736
Identifierdc.identifier.other10.1016/S0140-6736(16)00703-0
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/166791
Abstractdc.description.abstract© 2016 Elsevier Ltd Background Replacement of the trivalent oral poliovirus vaccine (tOPV) with bivalent types 1 and 3 oral poliovirus vaccine (bOPV) and global introduction of inactivated poliovirus vaccine (IPV) are major steps in the polio endgame strategy. In this study, we assessed humoral and intestinal immunity in Latin American infants after three doses of bOPV combined with zero, one, or two doses of IPV. Methods This open-label randomised controlled multicentre trial was part of a larger study. 6-week-old full-term infants due for their first polio vaccinations, who were healthy on physical examination, with no obvious medical conditions and no known chronic medical disorders, were enrolled from four investigational sites in Colombia, Dominican Republic, Guatemala, and Panama. The infants were randomly assigned by permuted block randomisation (through the use of a computer-generated list, block size 36) to nine groups, of which five will be discussed in this report. These fiv
Lenguagedc.language.isoen
Publisherdc.publisherLancet Publishing Group
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceThe Lancet
Keywordsdc.subjectMedicine (all)
Títulodc.titleHumoral and intestinal immunity induced by new schedules of bivalent oral poliovirus vaccine and one or two doses of inactivated poliovirus vaccine in Latin American infants: an open-label randomised controlled trial
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile