Show simple item record
Author | dc.contributor.author | Ramirez-Tagle, Rodrigo | |
Author | dc.contributor.author | Escobar, Carlos A. | |
Author | dc.contributor.author | Romero, Valentina | |
Author | dc.contributor.author | Montorfano, Ignacio | |
Author | dc.contributor.author | Armisén, Ricardo | |
Author | dc.contributor.author | Borgna, Vincenzo | |
Author | dc.contributor.author | Jeldes, Emanuel | |
Author | dc.contributor.author | Pizarro, Luis | |
Author | dc.contributor.author | Simon, Felipe | |
Author | dc.contributor.author | Echeverria, Cesar | |
Admission date | dc.date.accessioned | 2019-03-18T11:54:22Z | |
Available date | dc.date.available | 2019-03-18T11:54:22Z | |
Publication date | dc.date.issued | 2016 | |
Cita de ítem | dc.identifier.citation | International Journal of Molecular Sciences, Volumen 17, Issue 2, 2018, | |
Identifier | dc.identifier.issn | 14220067 | |
Identifier | dc.identifier.issn | 16616596 | |
Identifier | dc.identifier.other | 10.3390/ijms17020260 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/166813 | |
Abstract | dc.description.abstract | © 2016 by the authors; licensee MDPI, Basel, Switzerland. Hepatocellular carcinoma (HCC) is one of the most commonly diagnosed cancers worldwide. Chemoprevention of HCC can be achieved through the use of natural or synthetic compounds that reverse, suppress or prevent the development of cancer progression. In this study, we investigated the antiproliferative effects and the mechanism of action of two compounds, 2,3,4′-trimethoxy-2′-hydroxy-chalcone (CH1) and 3′-bromo-3,4-dimethoxy-chalcone (CH2), over human hepatoma cells (HepG2 and Huh-7) and cultured mouse hepatocytes (HepM). Cytotoxic effects were observed over the HepG2 and Huh-7, and no effects were observed over the HepM. For HepG2 cells, treated separately with each chalcone, typical apoptotic laddering and nuclear condensation were observed. Additionally, the caspases and Bcl-2 family proteins activation by using Western blotting and immunocytochemistry were studied. Caspase-8 was not activated, but caspase-3 and -9 were both a | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | MDPI AG | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | International Journal of Molecular Sciences | |
Keywords | dc.subject | Caspase | |
Keywords | dc.subject | Chalcone | |
Keywords | dc.subject | Reactive oxygen species | |
Título | dc.title | Chalcone-induced apoptosis through caspase-dependent intrinsic pathways in human hepatocellular carcinoma cells | |
Document type | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso Abierto | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
Files in this item
- Name:
- pdf
- Size:
- 8.668Mb
- Format:
- PDF
This item appears in the following Collection(s)
Show simple item record
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile