Show simple item record
Author dc.contributor.author Reyes-Farias, M.
Author dc.contributor.author Vasquez, K.
Author dc.contributor.author Fuentes, F.
Author dc.contributor.author Ovalle-Marin, A.
Author dc.contributor.author Parra-Ruiz, C.
Author dc.contributor.author Zamora, O.
Author dc.contributor.author Pino, M. T.
Author dc.contributor.author Quitral, V.
Author dc.contributor.author Jimenez, P.
Author dc.contributor.author Garcia, L.
Author dc.contributor.author Garcia-Diaz, D. F.
Admission date dc.date.accessioned 2019-03-18T11:54:53Z
Available date dc.date.available 2019-03-18T11:54:53Z
Publication date dc.date.issued 2016
Cita de ítem dc.identifier.citation Journal of Functional Foods, Volumen 27,
Identifier dc.identifier.issn 17564646
Identifier dc.identifier.other 10.1016/j.jff.2016.08.052
Identifier dc.identifier.uri https://repositorio.uchile.cl/handle/2250/166861
Abstract dc.description.abstract © 2016 Elsevier Ltd Obesity-associated insulin-resistance is set by a chronic inflammatory state established in the adipose tissue. Chilean native fruits calafate (CA) and maqui (MA) berries present remarkable anti-inflammatory features. Here, we evaluated antioxidant, anti-inflammatory and insulin-sensitizer effects of these fruits in an in vitro inflammatory setting. Differentiated 3T3-L1 cells exposed to conditioned media (CM) from activated macrophages were treated with CA and MA extracts. MA increased metalloproteinase (MMP)-2 activity on day 3, and both CA and MA modulated MMP-9 activity on day 10 of differentiation. In differentiated CM-treated 3T3-L1, extracts increased GSH levels and GSH/GSSG ratio, CA and MA prevented caspase-3 induction, and MA decreased MCP-1, while CA increased IL-6 gene expressions. Finally, MA reverted CM specific IRS-1 phosphorylation, and CA improved insulin-stimulated glucose uptake. Thus, treatments with extracts of Chilean native fruits were able to
Lenguage dc.language.iso en
Publisher dc.publisher Elsevier Ltd
Type of license dc.rights Attribution-NonCommercial-NoDerivs 3.0 Chile
Link to License dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Source dc.source Journal of Functional Foods
Keywords dc.subject Adipocytes
Keywords dc.subject Inflammation
Keywords dc.subject Insulin-resistance
Keywords dc.subject Macrophages
Keywords dc.subject Obesity
Keywords dc.subject Oxidative stress
Título dc.title Extracts of Chilean native fruits inhibit oxidative stress, inflammation and insulin-resistance linked to the pathogenic interaction between adipocytes and macrophages
Document type dc.type Artículo de revista
Cataloguer uchile.catalogador SCOPUS
Indexation uchile.index Artículo de publicación SCOPUS
uchile.cosecha uchile.cosecha SI
Files in this item
Name:
item_84987974040.pdf
Size:
2.171Kb
Format:
PDF
This item appears in the following Collection(s)
Show simple item record
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile