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Autophagy mediates calcium-sensing receptor-induced TNFα production in human preadipocytes

Authordc.contributor.authorMattar, Pamela 
Authordc.contributor.authorBravo Sagua, Roberto 
Authordc.contributor.authorTobar, Nicolás 
Authordc.contributor.authorFuentes, Cecilia 
Authordc.contributor.authorTroncoso, Rodrigo 
Authordc.contributor.authorBreitwieser, Gerda 
Authordc.contributor.authorLavandero González, Sergio 
Authordc.contributor.authorCifuentes, Mariana 
Admission datedc.date.accessioned2019-03-18T12:03:18Z
Available datedc.date.available2019-03-18T12:03:18Z
Publication datedc.date.issued2018
Cita de ítemdc.identifier.citationBiochimica et Biophysica Acta - Molecular Basis of Disease, Volumen 1864, Issue 11, 2018, Pages 3585-3594
Identifierdc.identifier.issn1879260X
Identifierdc.identifier.issn09254439
Identifierdc.identifier.other10.1016/j.bbadis.2018.08.020
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/167594
Abstractdc.description.abstract© 2018 Elsevier B.V. Obesity is a major current public health problem worldwide due to the severe co-morbid conditions that this disease entails. The development of obesity-related cardiometabolic disorders is in direct association with adipose tissue inflammation that leads to its functional impairment. Activation of the Calcium-Sensing Receptor (CaSR) in adipose tissue contributes to inflammation and adipose dysfunction. Autophagy, a process of cell component degradation, is closely related to inflammation in many diseases, however, whether autophagy is associated with CaSR-induced inflammation remains unknown. Using LS14 and SW872 preadipose cell lines as well as primary human preadipocytes, we show that CaSR activation with the allosteric activator cinacalcet induces autophagosome formation. Cinacalcet-induced LC3II content elevation was precluded by knockdown of the CaSR and enhanced by CaSR overexpression, indicating a specific effect. Autophagy inhibition using 3-methyladenine p
Lenguagedc.language.isoen
Publisherdc.publisherElsevier B.V.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceBiochimica et Biophysica Acta - Molecular Basis of Disease
Keywordsdc.subjectAutophagy
Keywordsdc.subjectCalcium-sensing receptor
Keywordsdc.subjectInflammation
Keywordsdc.subjectPreadipocyte
Títulodc.titleAutophagy mediates calcium-sensing receptor-induced TNFα production in human preadipocytes
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile