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Author dc.contributor.author Echeverría, F.
Author dc.contributor.author Valenzuela, R.
Author dc.contributor.author Espinosa, A.
Author dc.contributor.author Bustamante, A.
Author dc.contributor.author Álvarez, D.
Author dc.contributor.author González Mañan, Daniel
Author dc.contributor.author Ortiz, M.
Author dc.contributor.author Soto Alarcón, Sandra A.
Author dc.contributor.author Videla Cabrera, Luis
Admission date dc.date.accessioned 2019-03-18T12:03:49Z
Available date dc.date.available 2019-03-18T12:03:49Z
Publication date dc.date.issued 2019
Cita de ítem dc.identifier.citation Journal of Nutritional Biochemistry, Volumen 63,
Identifier dc.identifier.issn 18734847
Identifier dc.identifier.issn 09552863
Identifier dc.identifier.other 10.1016/j.jnutbio.2018.09.012
Identifier dc.identifier.uri https://repositorio.uchile.cl/handle/2250/167675
Abstract dc.description.abstract © 2018 Elsevier Inc. High-fat diet (HFD)-fed mice show obesity with development of liver steatosis and a proinflammatory state without establishing an inflammatory reaction. The aim of this work was to assess the hypothesis that eicosapentaenoic acid (EPA) plus hydroxytyrosol (HT) supplementation prevents the inflammatory reaction through enhancement in the hepatic resolvin content in HFD-fed mice. Male C57BL/6J mice were fed an HFD or a control diet and supplemented with EPA (50 mg/kg/day) and HT (5 mg/kg/day) or their respective vehicles for 12 weeks. Measurements include liver levels of EPA, DHA and palmitate (gas chromatography), liver resolvins and triglyceride (TG) and serum aspartate transaminase (AST) (specific kits) and hepatic and serum inflammatory markers (quantitative polymerase chain reaction and enzyme-linked immunosorbent assay). Compared to CD, HFD induced body weight gain, liver steatosis and TG accumulation, with up-regulation of proinflammatory markers in the absenc
Lenguage dc.language.iso en
Publisher dc.publisher Elsevier Inc.
Type of license dc.rights Attribution-NonCommercial-NoDerivs 3.0 Chile
Link to License dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Source dc.source Journal of Nutritional Biochemistry
Keywords dc.subject EPA
Keywords dc.subject Hepatic proinflammatory status
Keywords dc.subject High-fat diet
Keywords dc.subject Hydroxytyrosol
Keywords dc.subject Liver steatosis
Keywords dc.subject Resolvins
Título dc.title Reduction of high-fat diet-induced liver proinflammatory state by eicosapentaenoic acid plus hydroxytyrosol supplementation: involvement of resolvins RvE1/2 and RvD1/2
Document type dc.type Artículo de revista
Cataloguer uchile.catalogador SCOPUS
Indexation uchile.index Artículo de publicación SCOPUS
uchile.cosecha uchile.cosecha SI
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