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Author | dc.contributor.author | Villanueva, Andrea A. | |
Author | dc.contributor.author | Puvogel, Sofía | |
Author | dc.contributor.author | Lois, Pablo | |
Author | dc.contributor.author | Muñoz-Palma, Ernesto | |
Author | dc.contributor.author | Ramírez Orellana, Manuel | |
Author | dc.contributor.author | Lubieniecki, Fabiana | |
Author | dc.contributor.author | Casco Claro, Fernando | |
Author | dc.contributor.author | Gallegos, Iván | |
Author | dc.contributor.author | García-Castro, Javier | |
Author | dc.contributor.author | Sanchez-Gomez, Pilar | |
Author | dc.contributor.author | Torres, Vicente A. | |
Author | dc.contributor.author | Palma, Verónica | |
Admission date | dc.date.accessioned | 2019-03-18T12:03:49Z | |
Available date | dc.date.available | 2019-03-18T12:03:49Z | |
Publication date | dc.date.issued | 2018 | |
Identifier | dc.identifier.issn | 19336926 | |
Identifier | dc.identifier.issn | 19336918 | |
Identifier | dc.identifier.other | 10.1080/19336918.2018.1506652 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/167678 | |
Abstract | dc.description.abstract | © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. Neuroblastoma (NB) is the most common pediatric extracranial solid tumor. It arises during development of the sympathetic nervous system. Netrin-4 (NTN4), a laminin-related protein, has been proposed as a key factor to target NB metastasis, although there is controversy about its function. Here, we show that NTN4 is broadly expressed in tumor, stroma and blood vessels of NB patient samples. Furthermore, NTN4 was shown to act as a cell adhesion molecule required for the migration induced by Neogenin-1 (NEO1) in SK-N-SH neuroblastoma cells. Therefore, we propose that NTN4, by forming a ternary complex with Laminin γ1 (LMγ1) and NEO1, acts as an essential extracellular matrix component, which induces the migration of SK-N-SH cells. | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | Taylor and Francis Inc. | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Cell Adhesion and Migration | |
Keywords | dc.subject | basal lamina | |
Keywords | dc.subject | cell adhesion | |
Keywords | dc.subject | cell migration | |
Keywords | dc.subject | Laminin γ1 | |
Keywords | dc.subject | Neogenin-1 | |
Keywords | dc.subject | Netrin-4 | |
Keywords | dc.subject | Neuroblastoma | |
Título | dc.title | The Netrin-4/Laminin γ1/Neogenin-1 complex mediates migration in SK-N-SH neuroblastoma cells | |
Document type | dc.type | Artículo de revista | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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