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Authordc.contributor.authorSagredo, Eduardo A. 
Authordc.contributor.authorSagredo, Alfredo I. 
Authordc.contributor.authorBlanco, Alejandro 
Authordc.contributor.authorRojas De Santiago, Pamela 
Authordc.contributor.authorRivas, Solange 
Authordc.contributor.authorAssar Cuevas, Rodrigo 
Authordc.contributor.authorPérez, Paola 
Authordc.contributor.authorMarcelain Cubillos, Katherine 
Authordc.contributor.authorArmisen Yáñez, Ricardo 
Admission datedc.date.accessioned2020-06-22T22:52:29Z
Available datedc.date.available2020-06-22T22:52:29Z
Publication datedc.date.issued2020
Cita de ítemdc.identifier.citationBBA - Molecular Cell Research 1867 (2020) 118716es_ES
Identifierdc.identifier.other10.1016/j.bbamcr.2020.118716
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/175630
Abstractdc.description.abstractRNA editing has emerged as a novel mechanism in cancer progression. The double stranded RNA-specific adenosine deaminase (ADAR) modifies the expression of an important proportion of genes involved in cell cycle control, DNA damage response (DDR) and transcriptional processing, suggesting an important role of ADAR in transcriptome regulation. Despite the phenotypic implications of ADAR deregulation in several cancer models, the role of ADAR on DDR and proliferation in breast cancer has not been fully addressed. Here, we show that ADAR expression correlates significantly with clinical outcomes and DDR, cell cycle and proliferation mRNAs of previously reported edited transcripts in breast cancer patients. ADAR's knock-down in a breast cancer cell line produces stability changes of mRNAs involved in DDR and DNA replication. Breast cancer cells with reduced levels of ADAR show a decreased viability and an increase in apoptosis, displaying a significant decrease of their DDR activation, compared to control cells. These results suggest that ADAR plays an important role in breast cancer progression through the regulation of mRNA stability and expression of those genes involved in proliferation and DDR impacting the viability of breast cancer cells.es_ES
Patrocinadordc.description.sponsorshipComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT FONDECYT 3190738 1151446 1151435 Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) 21130361 21161206es_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherElsevieres_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Sourcedc.sourceBiochimica et Biophysica Acta-Molecular Cell Researches_ES
Keywordsdc.subjectBreast canceres_ES
Keywordsdc.subjectDNA damage responsees_ES
Keywordsdc.subjectProliferationes_ES
Keywordsdc.subjectRNA stabilityes_ES
Keywordsdc.subjectRNA editinges_ES
Títulodc.titleADAR1 Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA damage responsees_ES
Document typedc.typeArtículo de revistaes_ES
Catalogueruchile.catalogadorlajes_ES
Indexationuchile.indexArtículo de publicación ISIes_ES


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile