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ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans

Authordc.contributor.authorBoekstegers, Félix 
Authordc.contributor.authorMarcelain Cubillos, Katherine 
Authordc.contributor.authorBarahona Ponce, Carol 
Authordc.contributor.authorBáez Benavides, Pablo F. 
Authordc.contributor.authorMüller, Bettina 
Authordc.contributor.authorToro, Gonzalo de 
Authordc.contributor.authorRetamales, Javier 
Authordc.contributor.authorBarajas Barajas, Olga 
Authordc.contributor.authorAhumada Olea, Mónica 
Authordc.contributor.authorMorales, Erik 
Authordc.contributor.authorRojas, Armando 
Authordc.contributor.authorSanhueza, Verónica 
Authordc.contributor.authorLoader, Denisse 
Authordc.contributor.authorRivera, María Teresa 
Authordc.contributor.authorGutiérrez, Lorena 
Authordc.contributor.authorBernal, Giuliano 
Authordc.contributor.authorOrtega, Alejandro 
Authordc.contributor.authorMontalvo, Domingo 
Authordc.contributor.authorPortiño, Sergio 
Authordc.contributor.authorBertrán, María Enriqueta 
Authordc.contributor.authorGabler, Fernando 
Authordc.contributor.authorSpencer, Loreto 
Authordc.contributor.authorOlloquequi, Jordi 
Authordc.contributor.authorGonzález Silos, Rosa 
Authordc.contributor.authorFischer, Christine 
Authordc.contributor.authorScherer, Dominique 
Authordc.contributor.authorJenab, Mazda 
Authordc.contributor.authorAleksandrova, Krasimira 
Authordc.contributor.authorKatzke, Verena 
Authordc.contributor.authorWeiderpass, Elisabete 
Authordc.contributor.authorMoradi, Tahereh 
Authordc.contributor.authorFischer, Krista 
Authordc.contributor.authorBossers, Willem 
Authordc.contributor.authorBrenner, Hermann 
Authordc.contributor.authorHveem, Kristian 
Authordc.contributor.authorEklund, Niina 
Authordc.contributor.authorVölker, Uwe 
Authordc.contributor.authorWaldenberger, Melanie 
Authordc.contributor.authorFuentes Guajardo, Macarena 
Authordc.contributor.authorGonzález-José, Rolando 
Authordc.contributor.authorBedoya, Gabriel 
Authordc.contributor.authorBortolini, María C. 
Authordc.contributor.authorCanizales, Samuel 
Authordc.contributor.authorGallo, Carla 
Authordc.contributor.authorRuiz Linares, Andrés 
Authordc.contributor.authorRothhammer, Francisco 
Authordc.contributor.authorBermejo, Justo Lorenzo 
Admission datedc.date.accessioned2020-07-07T15:19:17Z
Available datedc.date.available2020-07-07T15:19:17Z
Publication datedc.date.issued2020
Cita de ítemdc.identifier.citationCancer Epidemiology 65 (2020) 101643es_ES
Identifierdc.identifier.other10.1016/j.canep.2019.101643
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/175825
Abstractdc.description.abstractBackground: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence. Methods: This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication. Results: Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low. Conclusion: Taking full advantage of genetic and ethnic differences in GBC risk may improve the efficiency of current prevention programs.es_ES
Patrocinadordc.description.sponsorshipFederal Ministry of Education & Research (BMBF) 01DN15021 European Union (FP7 Research infrastructures) within the initiative "Biobanking and Biomolecular Research Infrastructure -Large Prospective Cohorts" (Collaborative study "Identification of biomarkers for gallbladder cancer risk prediction Towards personali Germany's Excellence Initiative of Heidelberg University within the program "Mobilitaetsmassnahmen im Rahmen internationaler Forschungskooperationen 2015-16" support program "Stiftungen und Preise" of the Ruprecht-Karls-Universitaet Heidelberg German Research Foundation (DFG) LO 2061/1 Biobank of University of Chilees_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherElsevieres_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Sourcedc.sourceCancer Epidemiologyes_ES
Keywordsdc.subjectGallbladder canceres_ES
Keywordsdc.subjectPopulation-specific risk markeres_ES
Keywordsdc.subjectCancer epidemiologyes_ES
Keywordsdc.subjectNative American ancestryes_ES
Keywordsdc.subjectPueblosOriginarios_Uchile
Títulodc.titleABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileanses_ES
Document typedc.typeArtículo de revistaes_ES
dcterms.accessRightsdcterms.accessRightsAcceso Abierto
Catalogueruchile.catalogadorctces_ES
Indexationuchile.indexArtículo de publicación ISI
Indexationuchile.indexArtículo de publicación SCOPUS


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile