RvE1 Impacts the gingival inflammatory infiltrate by inhibiting the t cell response in experimental periodontitis
Author
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Álvarez, Carla
Author
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Abdalla, Henrique
Author
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Sulliman, Salwa
Author
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Rojas, Paola
Author
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Wu, Yu-Chiao
Author
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Almarhoumi, Rawan
Author
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Huang, Ren-Yeong
Author
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Galindo Díaz, Mario Alex
Author
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Vernal Astudillo, Rolando Marcelo
Author
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Kantarci, Alpdogan
Admission date
dc.date.accessioned
2022-01-28T14:05:19Z
Available date
dc.date.available
2022-01-28T14:05:19Z
Publication date
dc.date.issued
2021
Cita de ítem
dc.identifier.citation
Frontiers in Immunology May 2021 Volume 12 Article 664756
es_ES
Identifier
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10.3389/fimmu.2021.664756
Identifier
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https://repositorio.uchile.cl/handle/2250/183900
Abstract
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Periodontitis is a chronic inflammatory disease associated with the formation of dysbiotic
plaque biofilms and characterized by the progressive destruction of the alveolar bone. The
transition from health to disease is characterized by a shift in periodontal immune cell
composition, from mostly innate (neutrophils) to adaptive (T lymphocytes) immune
responses. Resolvin E1 (RvE1) is a specialized pro-resolution mediator (SPMs),
produced in response to inflammation, to enhance its resolution. Previous studies have
indicated the therapeutic potential of RvE1 in periodontal disease; however, the impact of
RvE1 in the microbial-elicited osteoclastogenic immune response remains
uncharacterized in vivo. In the present study, we studied the impact of RvE1 on the
gingival inflammatory infiltrate formation during periodontitis in a mouse model. First, we
characterized the temporal-dependent changes of the main immune cells infiltrating the
gingiva by flow cytometry. Then, we evaluated the impact of early or delayed RvE1
administration on the gingival immune infiltration and cervical lymph nodes composition.
We observed a consistent inhibitory outcome on T cells -particularly effector T cells- and a
protective effect on regulatory T cells (Tregs). Our data further demonstrated the wide
range of actions of RvE1, its preventive role in the establishment of the adaptive immune
response during inflammation, and bone protective capacity.
es_ES
Patrocinador
dc.description.sponsorship
United States Department of Health & Human Services
National Institutes of Health (NIH) - USA
NIH National Institute on Aging (NIA) R01AG062496
Chilean Government CONICYT 21161255
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Lenguage
dc.language.iso
en
es_ES
Publisher
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Frontiers Media
es_ES
Type of license
dc.rights
Attribution-NonCommercial-NoDerivs 3.0 United States