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Authordc.contributor.authorMorales Pisón, Sebastián
Authordc.contributor.authorJara Sosa, Lilian Elena Jonasa
Authordc.contributor.authorCarrasco, Valentina
Authordc.contributor.authorGutiérrez Vera, Cristian Alfonso
Authordc.contributor.authorReyes, José Miguel
Authordc.contributor.authorGonzález Hormazábal, Sebastián Patricio
Authordc.contributor.authorCarreño Márquez, Leandro Javier
Authordc.contributor.authorTapia Pineda, Julio César
Authordc.contributor.authorContreras Muñoz, Héctor Ruberly
Admission datedc.date.accessioned2022-11-24T12:37:21Z
Available datedc.date.available2022-11-24T12:37:21Z
Publication datedc.date.issued2022
Cita de ítemdc.identifier.citationInt. J. Mol. Sci. 2022, 23, 380es_ES
Identifierdc.identifier.other10.3390/ijms23010380
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/189344
Abstractdc.description.abstractMicroRNA-423 (miR-423) is highly expressed in breast cancer (BC). Previously, our group showed that the SNP rs6505162:C>A located in the pre-miR-423 was significantly associated with increased familial BC risk in patients with a strong family history of BC. Therefore, in this study, we evaluated the functional role of rs6505162 in mammary tumorigenesis in vitro to corroborate the association of this SNP with BC risk. We found that rs6505162:C>A upregulated expression of both mature miR-423 sequences (3p and 5p). Moreover, pre-miR-423-A enhanced proliferation, and promoted cisplatin resistance in BC cell lines. We also showed that pre-miR-423-A expression decreased cisplatin-induced apoptosis, and increased BC cell migration and invasion. We propose that the rs6505162-A allele promotes miR-423 overexpression, and that the rs6505162-A allele induces BC cell proliferation, viability, chemoresistance, migration, and invasion, and decreases cell apoptosis as a consequence. We suggest that rs6505162:C>A is a functional SNP site with potential utility as a marker for early diagnosis, prognosis, and treatment efficacy monitoring in BRCA1/2-negative BC patients, as well as a possible therapeutic target.es_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherMDPIes_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
Sourcedc.sourceInternational Journal of Molecular Scienceses_ES
Keywordsdc.subjectBreast canceres_ES
Keywordsdc.subjectMicroRNA functiones_ES
Keywordsdc.subjectMicroRNA-423es_ES
Keywordsdc.subjectFunctional studyes_ES
Títulodc.titleGenetic variation in MicroRNA-423 promotes proliferation, migration, invasion, and chemoresistance in breast cancer cellses_ES
Document typedc.typeArtículo de revistaes_ES
dc.description.versiondc.description.versionVersión publicada - versión final del editores_ES
dcterms.accessRightsdcterms.accessRightsAcceso abiertoes_ES
Catalogueruchile.catalogadorcrbes_ES
Indexationuchile.indexArtículo de publícación WoSes_ES


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Attribution-NonCommercial-NoDerivs 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States