Browsing by Author "García Nannig, Lorena"

Now showing items 21-40 of 52

    • Herpudl impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca2+-calcineurin-Akt ... 
      Navarro Márquez, Mario F.; Torrealba, Natalia; Troncoso, Rodrigo; Vásquez Trincado, César; Rodríguez, Marcelo; Morales, Pablo E.; Villalobos, Elisa; Eura, Yuka; García Nannig, Lorena; Chiong Lay, Mario; Klip, Amira; Jaimovich Pérez, Enrique; Kokame, Koichi; Lavandero González, Sergio (Elsevier, 2018)
      Skeletal muscle plays a central role in insulin-controlled glucose homeostasis. The molecular mechanisms related to insulin resistance in this tissue are incompletely understood. Herpud1 is an endoplasmic reticulum membrane ...
    • In cardiac fibroblasts and myofibroblasts Toll like receptor 4 (TLR4) activation releases proinflammatory ... 
      Humeres, D.; Boza Fuentes, Pía; Muñoz, C.; García Nannig, Lorena; Díaz Araya, Guillermo (Wiley-Blackwell, 2015)
    • Increased active phase atrial contraction is related to marathon runner performance 
      Gabrielli, Luigi; Herrera, Sebastián; Contreras Briceño, Felipe; Vega, Julián; Ocaranza, María Paz; Yáñez, Fernando; Fernández, Rodrigo; Saavedra, Rodrigo; Sitges, Marta; García Nannig, Lorena; Chiong Lay, Mario; Lavandero González, Sergio; Castro, Pablo F. (Springer Verlag, 2018)
      © 2018, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: Left atrial (LA) contraction is essential for left ventricular (LV) filling during exertion. We sought to evaluate the relationship of LA contraction ...
    • Increased Oxidative Stress Correlates With Pulmonary Vascular Response to Vasodilators in Pulmonary Artery ... 
      Castro Agüero, Pablo; Gabrielli, Luigi; Fasce, Fabrizio; Verdejo, Hugo; Greig, Douglas; Llevaneras, Silvana; Ferrada, Marcela; Hernández, Claudia; Godoy, Iván; García Nannig, Lorena; Mellado, Rose Marie; Sepúlveda, Pablo; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2009-03-10)
      Meeting Abstract
    • Increased rho-kinase activity in hypertensive patients with left ventricular hypertrophy 
      Gabrielli, Luigi A.; Winter, José L.; Godoy, Iván; McNab, Paul; Padilla, Ivonne; Córdova, Samuel; Rigotti, Paola; Novoa, Ulises; Mora, Italo; García Nannig, Lorena; Ocaranza, María P.; Jalil Milad, Jorge (Oxford University Press, 2014)
      background There is experimental evidence on the role of Rho-kinase (ROCK) activation in cardiac hypertrophy but no information on its role in human hypertension and left ventricular hypertrophy (LVH). We hypothesized that ...
    • Inflamación y disfunción endotelial en pacientes con insuficiencia cardiaca crónica 
      Greig, Douglas; Castro, Pablo; Gabrielli, Luigi A.; Miranda, Rodrigo; Verdejo, Hugo; Alcaíno Gálvez, Hernán Alejandro; Bustos, Carlos; Chiong Lay, Mario; Godoy, Iván; Mellado, Rose Marie; García Nannig, Lorena; Salas, Daniela; Vivar Sánchez, Raúl; Vukasovic Ramírez, José Luis; Concepción, Roberto; Díaz Araya, Guillermo (SOC MEDICA SANTIAGO, 2008-06)
      Background: In chronic heart failure (CHF), endothelial dysfunction (ED) is a consequence of an imbalance of vascular tone regulating substances. The relationship between ED and inflammation has not been fully investigated. ...
    • Influence of glucose metabolism on vascular smooth muscle cell proliferation 
      Chiong Lay, Mario; Morales, Pablo Esteban; Torres, Gloria; Gutiérrez, Tómas; García Nannig, Lorena; Ibacache, Mauricio; Michea Acevedo, Luis (Hans Huber, 2013)
      Diff erentiation of vascular smooth muscle cells (VSMC) is an essential process of vascular development. VSMC have biosynthetic, proliferative, and contractile roles in the vessel wall. Alterations in the diff erentiated ...
    • Interacción entre los polimorfismos del receptor ß1 y ß2 adrenérgico como predictor de riesgo de insuficiencia ... 
      Moraga, Francisco; Troncoso, Rodrigo; Mellado, Rose Marie; Díaz Araya, Guillermo; Vukasovic Ramírez, José Luis; Greig, Douglas; Pérez, Osvaldo; García Nannig, Lorena; Roldán, Juan; Ocaranza, María Paz; Jalil Milad, Jorge; Chiong Lay, Mario; Castro, Pablo (SOC MEDICA SANTIAGO, 2008-11)
      Background: beta adrenergic receptors (AR) are highly polymorphic and important regulators of cardiovascular homeostatis. Among these, beta(1) and beta(2) AR regulate cardiac contractility and frequency and are important ...
    • Iron induces protection and necrosis in cultured cardiomyocytes: Role of reactive oxygen species and nitric oxide 
      Muñoz, Juan Pablo; Chiong Lay, Mario; García Nannig, Lorena; Troncoso Cotal, Rodrigo; Toro, Barbra; Pedrozo Cibils, Zully; Díaz Elizondo, Jessica; Salas, Daniela; Parra Ortíz, María Valentina; Núñez González, Marco; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2010-02-15)
      We investigate here the role of reactive oxygen species and nitric oxide in iron-induced cardiomyocyte hypertrophy or cell death Cultured rat cardiomyocytes incubated with 20 mu M iron (added as FeCl3-Na nitrilotriacetate, ...
    • Markedly increased Rho-kinase activity in circulating leukocytes in patients with chronic heart failure 
      Ocaranza, María Paz; Gabrielli, Luigi; Mora, Italo; García Nannig, Lorena; McNab, Paul; Godoy, Iván; Braun, Sandra; Córdova, Samuel; Castro, Pablo; Novoa, Ulises; Chiong Lay, Mario; Lavandero González, Sergio; Jalil, E. (MOSBY-ELSEVIER, 2011-05)
      Background The small guanosine triphosphatase Rho and its target Rho-kinase have significant roles in experimental remodeling and ventricular dysfunction, but no data are available on Rho-kinase activation in patients with ...
    • Metabolismo energético del corazón y sus proyecciones en el tratamiento de la insuficiencia cardíaca 
      Castro, Pablo; Gabrielli, Luigi A.; Verdejo, Hugo; Greig, Douglas; Mellado, Rose Marie; Concepción, Roberto; Sepúlveda Morales, Luis; Vukasovic Ramírez, José Luis; García Nannig, Lorena; Pizarro, Marcela; Pivet, Deisy; Carrillo, Constanza; Tapia, Fabiola; Navarro, Mario; Troncoso, Rodrigo; Baraona, Fernando; Llevaneras, Silvana; Hernández, Claudia; Godoy, Iván; Jalil Milad, Jorge; Quintana, Juan Carlos; Orellana, Pilar; Chiong Lay, Mario; Lavandero González, Sergio (SOC MEDICA SANTIAGO, 2010-08)
      It is unknown why heart failure progresses even when patients are treated with the best therapy available. Evidences suggest that heart failure progression is due to loss of neurohumoral blockade in advanced stages of the ...
    • Microtubule proteins and their post-translational forms in the cerebrospinal fluid of patients with paraparesis ... 
      Maldonado, Horacio; Ortiz Riaño, Emilio Javier; Krause, Bernardo; Barriga, Andrés; Medina, Fernando; Pando, M. Elsa; Alberti, Carolina; Kettlun, Ana María; Collados, Lucía; García Nannig, Lorena; Cartier Rovirosa, Luis; Valenzuela Pedevila, María Antonieta (SOC BIOLGIA CHILE, 2008)
      HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is characterized by axonal degeneration of the corticospinal tracts. The specific requirements for transport of proteins and organelles to the distal ...
    • Mitochondria, myocardial remodeling, and cardiovascular disease 
      Verdejo, Hugo; Campo, Andrea del; Troncoso, Rodrigo; Gutiérrez, Tomás; Toro, Barbra; Quiroga, Clara; Pedrozo Cibils, Zully; Muñoz, Juan; García Nannig, Lorena; Castro, Pablo; Lavandero González, Sergio (2012)
      The process of muscle remodeling lies at the core of most cardiovascular diseases. Cardiac adaptation to pressure or volume overload is associated with a complex molecular change in cardiomyocytes which leads to anatomic ...
    • Novel players in cardioprotection: Insulin like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9) 
      Westermeier, Francisco; Bustamante, Mario; Pavez, Mario; García Nannig, Lorena; Chiong Lay, Mario; Ocaranza, María Paz; Lavandero González, Sergio (Elsevier, 2015)
      Insulin-like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9) have been proposed to be important mediators in cardioprotection. A large body of evidence indicates that insulin like growth factor-1 has pleotropic ...
    • Participación de lipoproteína de baja densidad oxidada (oxLDL) en la inducción de autofagia y sobrevida de ... 
      Ceballos Zúñiga, Gabriel Ignacio (Universidad de Chile, 2016)
      Las enfermedades cardiovasculares (ECV) son la principal causa de muerte en el mundo. Los elevados niveles de colesterol y lipoproteína de baja densidad (LDL), que se han relacionado a un aumento de la cantidad de LDL ...
    • Phospholipase C/protein kinase C pathway mediates angiotensin II-dependent apoptosis in neonatal rat cardiac ... 
      Sánchez Vivar, Raúl; Soto, Cristián; Copaja, Miguel; Mateluna Guajardo, María Francisca; Aránguiz Urroz, Pablo Daniel; Muñoz, Juan Pablo; Chiong Lay, Mario; García Nannig, Lorena; Letelier Vargas, Alan Gonzalo; Thomas, W. G.; Lavandero González, Sergio; Díaz Araya, Guillermo (LIPPINCOTT WILLIAMS & WILKINS, 2008-08)
      Cardiac fibroblasts are the major non-myocyte cell constituent in the myocardium, and they are involved in heart remodeling. Angiotensin II type I receptor (AT(1)R), and changes in its expression have been reported in ...
    • Pleiotropic effects of atorvastatin in heart failure: Role in oxidative stress, inflammation, endothelial ... 
      Castro, P.; Miranda, Rodrigo; Verdejo, Hugo; Greig, Douglas; Gabrielli, Luigi; Alcaíno Olivares, Hernán Alejandro; Chiong Lay, Mario; Bustos Contreras, Carlos Andrés; García Nannig, Lorena; Mellado, Rose Marie; Vukasovic Ramírez, José Luis; Godoy, Iván; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2008-04)
      Background: Increased oxidative stress, a common feature in chronic heart failure, has been associated with inflammation, endothelial dysfunction, and extracellular matrix degradation. Statins have known anti-inflammatory ...
    • Polymorphisms in the RAC1 gene are associated with hypertension risk factors in a chilean pediatric population 
      Tapia Castillo, Alejandra; Carvajal, Cristian A.; Campino, Carmen; Vecchiola, Andrea; Allende, Fidel; Solari, Sandra; García Nannig, Lorena; Lavandero González, Sergio; Valdivia, Carolina; Fuentes, Cristobal; Lagos, Carlos F.; Martínez Aguayo, Alejandro; Baudrand, René; Aglony, Marlene; García, Hernán; Fardella, Carlos E. (Oxford University Press, 2014)
      The GTPase Rac1 has been implicated in hypertension as a modulator of mineralocorticoid receptor activity. Our aim is to investigate the frequency of polymorphisms rs10951982 (intron 1, G>A) and rs836478 (intron 3, T>C) ...
    • Potato tuber isoapyrases: Substrate specificity, affinity labeling, and proteolytic susceptibility 
      Kettlun, Ana María; Espinosa, V.; García Nannig, Lorena; Valenzuela, María Antonieta (PERGAMON-ELSEVIER SCIENCE LTD, 2005-05)
      Apyrase/ATP-diphosphohydrolase hydrolyzes di- and triphosphorylated nucleosides in the presence of a bivalent ion with sequential release of orthophosphate. We performed studies of substrate specificity on homogeneous ...
    • Regulation of autophagy by Insulin/IGF-1 signaling pathways 
      Troncoso, Rodrigo; Vásquez Trincado, César; Campo, Andrea del; Gatica, Damián; Morales, Pablo; Paredes, Felipe; Gutiérrez, Tomás; López Crisosto, Camila; Lavandero González, Sergio; Torrealba, Natalia; García Nannig, Lorena; Díaz Araya, Guillermo; Battiprolu, Pavan K.; Nemchenko, Andriy; Ferdous, Anwarul; Gillette, Thomas G.; Hill, Joseph A. (Nova Science Publishers, 2012)