Browsing by Author "201-0010569"
Now showing items 41-60 of 103
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Squella Serrano, Juan; Núñez Vergara, Luis (1983)The interaction of glutathione with ampicillin was investigated by a new a.c. polarographic procedure. Ampicillin was found to interact strongly with glutathione. The stability constants were ascertained from the polarographic ...
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Núñez Vergara, Luis; Squella Serrano, Juan; Bollo Dragnic, Soledad; Marín Catalán, Rigoberto; Pino, L.; Díaz Araya, Guillermo; Letelier Muñoz, María Eugenia (PERGAMON-ELSEVIER SCIENCE LTD, 1998-01)1. Isradipine and lacidipine, two new drugs that are members of the nitro-aryl-1,4-dihydropyridine family, produced inhibition of both growth cultures and oxygen consumption on epimastigotes of Trypanosoma cruzi Tulahuen ...
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Jara Ulloa, Paola Andrea; Núñez Vergara, Luis; Squella Serrano, Juan (Wiley-V CH Verlag GMBH, 2007-07)Tne reductive electrochemistry of 1-methyl-4-nitro-2-hydroxymethylimidazole, a 4-nitroimidazole derivative, was examined in the presence of surfactants anionic as sodium dodecyl sulfate (SDS), nonionic, Triton-X, Cationic, ...
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Pizarro Urzúa, Nancy A.; Núñez Vergara, Luis (ELSEVIER SCIENCE SA, 2005-10-31)The ability to generate singlet molecular oxygen, O-2((1)Delta(g)), and the scavenging activity of two well-known 1,4-dihydropyridines (1,4-DHPs) such as nifedipine (1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridin ...
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Núñez Vergara, Luis; Aldunate, Jorge; Letelier Muñoz, María Eugenia; Bollo Dragnic, Soledad; Repetto Scaramelli, Yolanda; Morello Casté, Antonio; Spencer, P. L.; Squella Serrano, Juan (Elsevier, 1995)The cyclic voltammetric (CV) behaviour of nifurtimox was studied. The addition of aprotic solvent (DMF) to nifurtimox in an aqueous citrate buffer system was examined. Qualitatively this results in separation of the initial ...
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Argüello da Silva, Jacqueline; Núñez Vergara, Luis; Bollo Dragnic, Soledad; Squella Serrano, Juan (ELSEVIER SCIENCE SA, 2006-09)Three new nitrofuryl substituted 1,4-dihydropyridine derivatives were electrochemically tested in the scope of newly found compounds useful as chemotherapeutic alternative to the Chagas' disease. All the compounds were ...
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Bontá, M.; Chauviere, G.; Perie, J.; Núñez Vergara, Luis; Squella Serrano, Juan (PERGAMON-ELSEVIER SCIENCE, 2002-09-25)We have studied the electrochemical reduction of some nitroimidazoles such as megazol(2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazol, CAS 19622-55-0) and two related derivatives in aprotic media (100% DMF, 0.1 ...
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Letelier Muñoz, María Eugenia; Entrala Alrruiz, Paz Andrea; López Alarcón, Camilo; González Lira, Víctor; Molina Berríos, Alfredo Enrique; Cortés Troncoso, Juan; Jara Sandoval, José; Santander, P.; Núñez Vergara, Luis (PERGAMON-ELSEVIER SCIENCE, 2007-12)1,4-Dihydropyridines (DHPs) used in the treatment of cardiovascular diseases, are calcium channel antagonists and also antioxidant agents. These drugs are metabolized through cytochrome P-450 oxidative system, majority ...
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Merino, M.; Carbajo, J.; Núñez Vergara, Luis; Squella Serrano, Juan (SOCIEDAD CHILENA DE QUIMICA, 2000-03)The electrochemical nitroreduction of nitrofurantoin has been studied on carbon paste and glassy carbon electrodes. We can observe a monoelectronic reversible couple ArNO2/ArNO2- and an irreversible peak due to the further ...
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Bollo Dragnic, Soledad; Núñez Vergara, Luis; Barrientos Vargas, Claudia Marjorie; Squella Serrano, Juan (WILEY-V C H VERLAG GMBH, 2005-09)The electrochemical behavior of iodo nitroimidazole derivatives such as 1-methyl-4-iodo-5-nitroimidazole (M-I-NIm) and 1-methyl-2,4-diiodo-5-nitroimidazole (M-I-2-NIm) and the parent compound 1-methyl-5-nitroimidazole ...
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Núñez Vergara, Luis; Squella Serrano, Juan; Olea Azar, Claudio; Bollo Dragnic, Soledad; Navarrete Encina, Patricio; Sturm Schaub, Juan (PERGAMON-ELSEVIER SCIENCE, 2000)This paper reports both the electrochemical characterization and the reactivity of the nitroso radical anion from nitrosobenzene with glutathione. The reduction of nitrosobenzene to the corresponding nitroso radical anion ...
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Salazar González, Ricardo Andrés; Navarrete Encina, Patricio; Camargo Grandón, Rodrigo; Squella Serrano, Juan; Núñez Vergara, Luis (ELECTROCHEMICAL SOC INC, 2008)Electrochemical oxidation of 4-(3-indolyl)- and 4-(5-indolyl)-1,4-dihydropyridines (DHPs) in aprotic and protic media is reported. Also, the reactivity of compounds toward alkylperoxyl radicals 2,2'-azobis-(2-amidinopropane) ...
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Ortíz Yáñez, María Eugenia; Núñez Vergara, Luis; Camargo Grandón, Rodrigo; Squella Serrano, Juan (KLUWER ACADEMIC/PLENUM PUBL, 2004-03)The final pyridine derivatives were separated and identified by gas chromatography/ mass spectrometry (GC-MS). The intermediates, anion dihydropyridine and the HO2./HO2- species, were observed from voltammetric studies and ...
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Galvis Pareja, David Andrés (Universidad de ChileCyberDocs, 2011)
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Pizarro Urzúa, Nancy A.; Günther Sapunar, Germán; Núñez Vergara, Luis (ELSEVIER SCIENCE, 2007-06-10)A different photophysical and photochemical behavior has been found between two second generation antihypertensive 1,4-dihydropyitidines (1,4-DHPs), felodipine and nimodipine. While nimodipine was observed as being more ...
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Bollo Dragnic, Soledad; Núñez Vergara, Luis; Bontá, M.; Chauviere, G.; Perie, J.; Squella Serrano, Juan (WILEY-V C H VERLAG GMBH, 2001-07)Megazol (2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazol, CAS 19622-55-0), a highly active compound used against several of Trypanosoma cruzi, the causative agent of Chagas disease, is electrochemically studied ...
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Squella Serrano, Juan; Muñoz, W.; Núñez Vergara, Luis; Paulos, Claudio (AMER PHARMACEUTICAL ASSN, 1990)Nifurtimox is polarographically reducible over the whole pH range, the nitro group being reduced to the hydroxylamine group in a 4ē process and subsequently the amine being formed in a 2ē process at a pH value below 4. The ...
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Salazar González, Ricardo Andrés (Universidad de ChileCyberDocs, 2008)
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López Alarcón, Camilo; Rocco Klein, Claudio Alberto; Lissi Gervaso, Eduardo A.; Carrasco, C.; Squella Serrano, Juan; Núñez Vergara, Luis; Speisky Cosoy, Hernán (SPRINGER/PLENUM PUBLISHERS, 2005-10)Purpose. The aims of the study are to analyze the interaction between 5-aminosalicylic acid (5-ASA) and peroxyl radicals and to evaluate the effect of some endogenous compounds such as ascorbic acid and amino acids on the ...
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López Alarcón, Camilo; Navarrete Encina, Patricio; Camargo Grandón, Rodrigo; Squella Serrano, Juan; Núñez Vergara, Luis (AMER CHEMICAL SOC, 2003-02)A series of C4-substituted 1,4-dihydropyridines (DHP) with either secondary or tertiary nitrogen in the dihydropyridine ring were synthesized. All of these compounds together with some commercial DHP derivatives were tested ...