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Tiroides y depresión. Enfoque terapéutico actual y bases moleculares
(2007)
de 80 a 90%, es de 6 por cien mil habi-
tantes. Actualmente, los ISRS (inhibidores selectivos
Rev. Hosp. Clín. Univ. Chile 2007; 18; 220 - 6
www.redclinica.cl 221
de la recaptación de serotonina) son los fármacos más
usados debido a su buena...
la D2: DII- Thr92Ala y DII-ORFa-Gly3Asp. Cambios sutiles SEROTONINA POTENCIACIóN DE EFECTO ANTIDEPRESIVO t3t4 t2di-2 di-3 (+) (-) Figura 1. Hormonas tiroideas y efecto antidepresivo de los inhibidores selectivos de la recaptación de serotonina (ISRS...
la D2: DII- Thr92Ala y DII-ORFa-Gly3Asp. Cambios sutiles SEROTONINA POTENCIACIóN DE EFECTO ANTIDEPRESIVO t3t4 t2di-2 di-3 (+) (-) Figura 1. Hormonas tiroideas y efecto antidepresivo de los inhibidores selectivos de la recaptación de serotonina (ISRS...
Antigen presentation unfolded: identifying convergence points between the UPR and antigen presentation pathways
(Elsevier, 2018-06)
inhibition or
viral infection (Figure 1 and Figure 3).
Activation of the PERK branch (as well as three other
kinases of different stress pathways collectively referred
to as the ‘integrated stress response’ (ISR)) [52] (see
Figure 3) induces phosphorylation...
prote P P P Pcodon initiation, representing a shift in antigens and modulating T cell immune response [50]. Besides the initiation of alternative translation, the ISR is also important for the induction of autophagy. A systems biology approach...
prote P P P Pcodon initiation, representing a shift in antigens and modulating T cell immune response [50]. Besides the initiation of alternative translation, the ISR is also important for the induction of autophagy. A systems biology approach...
Diseño e implementación de una puerta de seguridad inteligente para infantes como un producto para el comercio masivo
(Universidad de Chile, 2021)
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49
4.3. Consumo energético del sistema embebido para cada modo de funcionamiento.
No se incluyen tiempos de ejecución, ya que son dependientes de la activación
de las ISR, ante la detección de E1 y E2. . . . . . . . . . . . . . . . . . . . . 50
4...
A model for social networks data management
(Universidad de Chile, 2012)
Drug repurposing to target proteostasis and prevent neurodegeneration: accelerating translational efforts
(Oxford University Press, 2017-06)
stress response’ (ISR) (Pakos-
Zebrucka et al., 2016).
Phosphorylation of eIF2a also allows
the translation of certain mRNAs con-
taining short open reading frames in
the 5’-untranslated region, leading to
expression of activating transcription
factor 4...
). These biological activities are shared with other kinases of the ISR pathway, as reported in functional studies aimed at manipulating PKR and GCN2 in the context of synaptic plasticity and Alzheimer’s disease. Recent drug dis- covery efforts to target the PERK/ e...
). These biological activities are shared with other kinases of the ISR pathway, as reported in functional studies aimed at manipulating PKR and GCN2 in the context of synaptic plasticity and Alzheimer’s disease. Recent drug dis- covery efforts to target the PERK/ e...
Impact of mitophagy and mitochondrial unfolded protein response as new adaptive mechanisms underlying old pathologies: sarcopenia and non-alcoholic fatty liver disease
(MDPI, 2020)
. Nevertheless, the role of the integrated stress response (ISR) involving UPRmt and mitophagy in the development and progression of these illnesses is still a matter of debate, considering that some studies indicate that the prolonged exposure to low levels...
Seguimiento y optimización de la farmacoterapia de pacientes adultos mayores hospitalizados en una unidad geriátrica de agudos
(Universidad de Chile, 2016)
antidepresivos ISRS (14,9%), antipsicóticos (59,7%) y benzodiacepinas (9,0%). Además, se observó que los pacientes que egresan de UGA con al menos un MPI registran valores de EVA de la escala EQ-5D menores a los registrados por los pacientes que egresan sin este...
The increased aging, the large amount of co-morbidities suffering by the older adults and the increased use of medicaments lead an increased risk of Potential Inappropriate Medication (PIM) use and Drug-Related Problem (DRP). With the purpose of prevent inappropriate prescribing, a prospective follow up study was conducted in a sample of inpatients in Acute Geriatric Unit (AGU) at the Hospital Clínico de la Universidad de Chile (HCUCH), elderly ≥ 65 years old who stay at least 3 days in the unit were included. The pharmacological follow up was made for 6 months, through of interviews to the inpatients and family, complemented with the information of the electronic files of HCUCH, evaluating medical treatments and intervening in case where PIM and DRP were detected. For detection of PIM, the 2015 Beers Criteria and STOPP&START Criteria (version 2) were used as screening tools and the DRP were defined according to the Minnesota Project. During the study, 75 patients were enrolled according to the selection criteria, of which 60% were women and 40% were men, with a mean age of 82.4 ± 7.5 years old, 5.0 ± 2.5 co-morbidities and of 5.8 ± 2.5 medications/day. The prevalence of prescription of PIM according the 2015 Beers Criteria was 60%, 62.7% and 30.1% at admission, during the stay and at discharge, respectively, while the prevalence of prescription of PIM according the STOPP criteria was 58.7%, 49.3% and 30.1% at admission, during the stay and at discharge, respectively. The most common PIM during the hospitalization were SSRI antidepressants (14.9%) antipsychotics (59.7%) and benzodiazepines (9.0%) at admission and during hospitalization. Furthermore, the patients with at least one PIM, at discharge, present lower values of VAS of EQ-5D scale than patients without PIM at discharge (69.2% vs 77.9%). During follow up period, 122 DRP were detected. The most common DRP were unnecessary prescribing in the 47.5% (n=58) of the patients, related with the omeprazole use, and the problem untreated in the 12.3% (n=15) of the patients, related the lactulose use. The main pharmaceutical interventions were the recommendation of stop the drug therapy (28.1%), and the provide information on adherence of treatment to patients and their families (13.9%). Through the pharmaceutical followed up and the interventions lead decreased the prevalence of PIM of 16% until 6.4% according the Beers Criteria and of 13.3% until 5.7% according the STOPP Criteria. This way, was achieved the optimization of pharmacotherapy in the patients studied, preventing the PIM use and can improve the health-related of quality life...
The increased aging, the large amount of co-morbidities suffering by the older adults and the increased use of medicaments lead an increased risk of Potential Inappropriate Medication (PIM) use and Drug-Related Problem (DRP). With the purpose of prevent inappropriate prescribing, a prospective follow up study was conducted in a sample of inpatients in Acute Geriatric Unit (AGU) at the Hospital Clínico de la Universidad de Chile (HCUCH), elderly ≥ 65 years old who stay at least 3 days in the unit were included. The pharmacological follow up was made for 6 months, through of interviews to the inpatients and family, complemented with the information of the electronic files of HCUCH, evaluating medical treatments and intervening in case where PIM and DRP were detected. For detection of PIM, the 2015 Beers Criteria and STOPP&START Criteria (version 2) were used as screening tools and the DRP were defined according to the Minnesota Project. During the study, 75 patients were enrolled according to the selection criteria, of which 60% were women and 40% were men, with a mean age of 82.4 ± 7.5 years old, 5.0 ± 2.5 co-morbidities and of 5.8 ± 2.5 medications/day. The prevalence of prescription of PIM according the 2015 Beers Criteria was 60%, 62.7% and 30.1% at admission, during the stay and at discharge, respectively, while the prevalence of prescription of PIM according the STOPP criteria was 58.7%, 49.3% and 30.1% at admission, during the stay and at discharge, respectively. The most common PIM during the hospitalization were SSRI antidepressants (14.9%) antipsychotics (59.7%) and benzodiazepines (9.0%) at admission and during hospitalization. Furthermore, the patients with at least one PIM, at discharge, present lower values of VAS of EQ-5D scale than patients without PIM at discharge (69.2% vs 77.9%). During follow up period, 122 DRP were detected. The most common DRP were unnecessary prescribing in the 47.5% (n=58) of the patients, related with the omeprazole use, and the problem untreated in the 12.3% (n=15) of the patients, related the lactulose use. The main pharmaceutical interventions were the recommendation of stop the drug therapy (28.1%), and the provide information on adherence of treatment to patients and their families (13.9%). Through the pharmaceutical followed up and the interventions lead decreased the prevalence of PIM of 16% until 6.4% according the Beers Criteria and of 13.3% until 5.7% according the STOPP Criteria. This way, was achieved the optimization of pharmacotherapy in the patients studied, preventing the PIM use and can improve the health-related of quality life...
Análisis Comparativo de las Diferencias Entre Países en las Evaluaciones Internacionales de Aprendizaje en el Período 1995 – 2006
(Universidad de ChilePrograma Cybertesis, 2008)
Medicamentos potencialmente inapropiados en pacientes geriátricos post alta : criterios beers versus stopp & start
(Universidad de Chile, 2014)
terapéuticos más comúnmente identificados como PMPI fueron los antiarrítmicos según criterio de Beers 2003 (57,9%) y los ISRS (inhibidores selectivos de recaptación de serotonina) según criterio de Beers 2012 (29,4%) mientras que para STOPP los antiagregantes...
Introduction: The Beers criteria and the STOPP detection (Screening Tool of Older Persons’ Prescriptions) are the most common instruments to detect the prescription of potentially inappropriate medications (PIMs) on older adults (OA). However, there are no Chilean study that compares the detection capacity on PIMs and its consequences in post discharge patients. Objective: The purpose of the present study was to compare the detection capacity of the Beers Criteria (2003, 2012) versus STOPP & START (Screening Tool to Alert to Right Treatment) of adverse clinical consequences in post discharged patients at the Unidad Geriátrica de Agudos del Hospital Clínico de la Universidad de Chile. Method: It was performed a pilot prospective cohort study on 42 post discharged OA, where 36 patients completed the study. Once the patients were discharged, and those who satisfied the selection criteria including patients’ ≥ 65 years old, of both sex, with proved telephone contact, who accepted to participate in the study and signed informed consent. Patients were subjected to a telephone follow-up for three months to assess the use of PIMs and the occurrence of adverse clinical outcomes. Results: The frequency of PIMs increased within discharge and the third month of follow-up, from 1,3% to 3,4% according to the Beers Criteria 2003, from 11% to 16, 5% according to the Beers Criteria 2012, from 7,2% to 10,8% according to STOPP, and from 8,4% to 11,4% according to START. The therapeutic groups most commonly identified as PIMs were the anti-arrhythmics according to the Beers criteria 2003 (57,9%) and the selective serotonin reuptake inhibitors (SSRIs) according to the Beers criteria 2012 (29,4%), while for STOPP the platelet inhibitors (27,7%) and for START the statins (40%). The association between the evaluated clinical outcomes and the different criteria used didn’t result statistically significant. Conclusion: The results of the present study concludes that the frequency of PIMs in a sample of OA “post discharge” varies depending on the criteria used and the elapsed time within discharge and the third month of follow-up. For the detection of adverse clinical consequences it becomes necessary to conduct further studies with a larger population sample...
Introduction: The Beers criteria and the STOPP detection (Screening Tool of Older Persons’ Prescriptions) are the most common instruments to detect the prescription of potentially inappropriate medications (PIMs) on older adults (OA). However, there are no Chilean study that compares the detection capacity on PIMs and its consequences in post discharge patients. Objective: The purpose of the present study was to compare the detection capacity of the Beers Criteria (2003, 2012) versus STOPP & START (Screening Tool to Alert to Right Treatment) of adverse clinical consequences in post discharged patients at the Unidad Geriátrica de Agudos del Hospital Clínico de la Universidad de Chile. Method: It was performed a pilot prospective cohort study on 42 post discharged OA, where 36 patients completed the study. Once the patients were discharged, and those who satisfied the selection criteria including patients’ ≥ 65 years old, of both sex, with proved telephone contact, who accepted to participate in the study and signed informed consent. Patients were subjected to a telephone follow-up for three months to assess the use of PIMs and the occurrence of adverse clinical outcomes. Results: The frequency of PIMs increased within discharge and the third month of follow-up, from 1,3% to 3,4% according to the Beers Criteria 2003, from 11% to 16, 5% according to the Beers Criteria 2012, from 7,2% to 10,8% according to STOPP, and from 8,4% to 11,4% according to START. The therapeutic groups most commonly identified as PIMs were the anti-arrhythmics according to the Beers criteria 2003 (57,9%) and the selective serotonin reuptake inhibitors (SSRIs) according to the Beers criteria 2012 (29,4%), while for STOPP the platelet inhibitors (27,7%) and for START the statins (40%). The association between the evaluated clinical outcomes and the different criteria used didn’t result statistically significant. Conclusion: The results of the present study concludes that the frequency of PIMs in a sample of OA “post discharge” varies depending on the criteria used and the elapsed time within discharge and the third month of follow-up. For the detection of adverse clinical consequences it becomes necessary to conduct further studies with a larger population sample...
Predicción computacional de genes de ARN no codificante pequeño en genomas bacterianos
(Universidad de Chile, 2012)