Browsing by Author "Olea Azar, Claudio"
Now showing items 21-40 of 106
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Olea Azar, Claudio; Parra Mouchet, Julia (Elsevier, 1997)Conformational analysis of famotidine (FAMO) and some analogues have been performed using AM1 calculations. In addition, conformational analysis were done on the 2-guanidinylthiazole moiety in order to see the effect of ...
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Zúñiga, María A.; Pérez Roa, Rodolfo E.; Olea Azar, Claudio; Laurie, V. Felipe; Agosin Trumper, Eduardo (Elsevier, 2014)In this research, we determined the chemical composition of 37 Vitis vinifera cv. Carme´ne` re wines and established their antioxidant capacity (AC). A set of 26 measurements of chemical species potentially related to ...
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Paris Pizarro, Irmgard; Dagnino Subiabre, Alexies; Marcelain Cubillos, Katherine; Bennett, L. B.; Caviedes Fernández, Pablo; Caviedes Codelia, Raúl; Olea Azar, Claudio; Segura Aguilar, Juan (BLACKWELL SCIENCE LTD, 2001-04)The mechanism of copper (Cu) neurotoxicity was studied in the RCSN-3 neuronal dopaminergic cell line, derived from substantia nigra of an adult rat. The formation of a Cu-dopamine complex was accompanied by oxidation of ...
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Speisky Cosoy, Hernán; Gómez, Maritza; Carrasco Pozo, Catalina; Pastene, Edgar; López Alarcón, Camilo; Olea Azar, Claudio (2008)Cu(2+) ions and and GSH molecules interact swiftly to form the complex Cu(I)–glutathione. We investigated the potential capacity of such complex to reduce molecular oxygen. The addition of SOD to a solution containing ...
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Cyclic voltammetric and EPR spectroscopic studies of benzodiazepines: Loprazolam and flunitrazepam Núñez Vergara, Luis; Bollo Dragnic, Soledad; Olea Azar, Claudio; Navarrete-Encina, Patricio; Squella Serrano, Juan (Elsevier, 1997)The present paper reports on the electrochemical characterization by cyclic voltammetry of two 1,4-benzodiazepines, loprazolam and flunitrazepam in protic, aprotic and mixed media. In protic media (ethanol + 15 mM citrate ...
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Jullian Matthaei, Carolina; Brossard, Victor; González, Iván; Alfaro, Muriel; Olea Azar, Claudio (SPRINGER/PLENUM PUBLISHERS, 2011-04)The slightly water-soluble flavonoid kaempferol (KAE) and its inclusion complexes with beta-cyclodextrin (beta CD), hydroxypropyl-beta-cyclodextrin (HP beta CD) or heptakis-2,6-O-dimethyl-beta-cyclodextrin (DM beta CD) ...
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Toro, Patricia; Suazo, Constanza; Acuña, Alejandra; Fuentealba, Mauricio; Artigas, Vania; Arancibia, Rodrigo; Olea Azar, Claudio; Moncada, Mauricio; Wilkinson, Shane; Klahn, A. Hugo (Elsevier, 2018)A novel series of cyrhetrenyl (3a-4a) and ferrocenyl (3b-4b) Schiff bases were synthesized through a condensation reaction, between the known 4-ferrocenylaniline (2b) or the unreported 4-cyhretrenylaniline (2a) with 4-or ...
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Espinoza, Mónica; Olea Azar, Claudio; Speisky Cosoy, Hernán; Rodríguez Borges, Jorge (PERGAMON-ELSEVIER SCIENCE LTD, 2009-01)Four different types of Chilean wines (Cabernet Sauvignon, Merlot, Carmenere and Syrah) were selected and examined in their free radical scavenging capacities by electron spin resonance (ESR) and spectrophotometric methods. ...
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Espinoza, M.; Olea Azar, Claudio; Massif, G.; Villa Litovosky, Alberto (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2008-12)Reference materials are essential tools to achieve comparability and traceability between measurements. However, reference materials in food matrices are scarce. in this article, the development of a reference material for ...
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Núñez Vergara, Luis; Pardo Jiménez, V; Barrientos, C.; Olea Azar, Claudio; Navarrete-Encina, P. A.; Squella Serrano, Juan (2012)In this study, two series of dihydropyridine-fused and pyridine-fused coumarins were synthesised and electrochemically characterised in aprotic medium. In both series, the most easily reducible groups were the endocyclic ...
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González Fuentes, Pamela A.; Zúniga López, María C.; Olea Azar, Claudio; Loyola, Cristina; Folch Cano, Christian G. (Pontificia Universidad Católica de Chile, 2017)The production of high quality natural Antioxidants from olive pruning wood extracts and their application to prevent the oxidation of vegetable oils were evaluated. The production of antioxidants from branches of olive ...
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Aguilera Venegas, Benjamín; Olea Azar, Claudio; Arán, Vicente J.; Maya Arango, Juan; Kemmerling Weis, Ulrike; Speisky Cosoy, Hernán; Mendizábal Emaldía, Fernando (2012)A comprehensive multidisciplinary study is conducted here in order to assess the electrochemical behavior of a series of 1,1'-hydrocarbylenebisindazoles derivatives and its potential use as anti-T.cruzi drugs. At first, ...
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Barriga González, Germán; Olivares Petit, Carla; Toro, Patricia M.; Klahn, A. Hugo; Olea Azar, Claudio; Maya Arango, Juan D.; Huentupil, Yosselin; Arancibia, Rodrigo (Soc. Chilena de Química, 2020)The bioorganometallic compounds 2-cyrhetrenyl-5-nitro-benzimidazole (Bzn-1) and 2-ferrocenyl-5-nitro-benzimidazole (Bzn-2) have been proposed as potential anti-Trypanosoma cruzi agents. In this regard, electrochemical, ...
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Olea Azar, Claudio; Alarcón, J.; Opazo, L.; Abarca, B.; Ballesteros, R.; Bielsa, P. (Sociedad Chilena de Quimica, 2002)Apomorphine acts as contractile muscular agent through an extra cellular calcium mechanism dependent. This activity is accompanied with autoxidacion process producing o-quinone derivates. o-Quinone is also obtained by ...
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Olea Azar, Claudio; Abarca, B.; Norambuena, E.; Opazo, L.; Rigol, C.; Ballesteros, R.; Chadlaoui, M. (2005)The ESR spectra of radicals obtained by electrolytic reduction of 2-acylpyridines and 6,6′-diacyl-2,2′-bipyridines were measured in dimethylsulfoxide (DMSO) and analyzed by quantum chemical calculations. The electrochemistry ...
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Aravena, María C.; Figueroa, Roberto; Olea Azar, Claudio; Arán, Vicente J. (2010)Cyclic Voltammetry (CV) and electron spin resonance (ESR) techniques were used in the investigation of several potentially antiprotozoal nitro derivatives of dihydroquinoxaline and indazole. A self-protonation process ...
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Folch Cano, Christian (Universidad de ChileCyberDocs, 2011)
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Mura Mardones, Francisco (Universidad de Chile, 2016)Los ácidos hidroxicinámicos (ácidos p-cumárico, cafeico, ferúlico y sinápico, entre otros) son compuestos fenólicos que se encuentran ampliamente distribuidos en alimentos de origen vegetal. Su estructura química le permite ...
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Aravena Castro, María de los Ángeles (Universidad de Chile, 2016)La presente tesis doctoral exhibe un estudio químico y biológico de dos familias de nitrocompuestos: derivados de Nitrofurano y derivados de Nitroindazol, con el propósito principal de obtener nuevos aspectos acerca de ...
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Mercado Muñoz, Roberto Andrés (Universidad de Chile, 2010)Este estudio fue desarrollado para investigar los mecanismos de reducción y reactividad de una nueva familia 5-Nitroindazoles. Estos compuestos poseen actividad radicalaria a partir de su grupo nitro, razón por la cual son ...