About
Contact
Help
Sending publications
How to publish
Advanced Search
View Item 
  •   Home
  • Facultad de Ciencias
  • Artículos de revistas
  • View Item
  •   Home
  • Facultad de Ciencias
  • Artículos de revistas
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse byCommunities and CollectionsDateAuthorsTitlesSubjectsThis CollectionDateAuthorsTitlesSubjects

My Account

Login to my accountRegister
Biblioteca Digital - Universidad de Chile
Revistas Chilenas
Repositorios Latinoamericanos
Tesis LatinoAmericanas
Tesis chilenas
Related linksRegistry of Open Access RepositoriesOpenDOARGoogle scholarCOREBASE
My Account
Login to my accountRegister

Sonic Hedgehog Stimulates Proliferation of Human Periodontal Ligament Stem Cells

Artículo
Thumbnail
Open/Download
IconMartinez_C.pdf (564.2Kb)
Publication date
2011-04
Metadata
Show full item record
Cómo citar
Martínez, C.
Cómo citar
Sonic Hedgehog Stimulates Proliferation of Human Periodontal Ligament Stem Cells
.
Copiar
Cerrar

Author
  • Martínez, C.;
  • Smith, P. C.;
  • Rodriguez, J. P.;
  • Palma Alvarado, Verónica;
Abstract
Regulation of cell renewal in the periodontium is a critical cell function that has not been clarified. Sonic hedgehog (Shh) is a secreted signaling molecule that plays a key role during development and adult tissue homeostasis. In the present study, we have analyzed the role played by Shh in human periodontal ligament stem cell (HPLSC) proliferation. HPLSC were isolated with anti-STRO-1 antibodies. Shh increased the expression of GLI1 and PTC-1 and selectively stimulated cell proliferation in STRO-1(+) derived from adult periodontal ligament. Shh components were localized to primary cilia in STRO-1(+) cells after Shh stimulation. STRO-1(+) also expressed Shh, suggesting an autocrine-regulated phenomenon. Thus, we propose that Shh plays a critical role in the regulation of cell proliferation in STRO-1(+)/HPLSC.
General note
Artículo de publicación ISI
Patrocinador
CONICYT ICM-CGC P06-039F FONDECYT 1090093 1070248 1090142
Identifier
URI: https://repositorio.uchile.cl/handle/2250/119368
DOI: DOI: 10.1177/0022034510391797
ISSN: 0022-0345
Quote Item
JOURNAL OF DENTAL RESEARCH Volume: 90 Issue: 4 Pages: 483-488 Published: APR 2011
Collections
  • Artículos de revistas
xmlui.footer.title
31 participating institutions
More than 73,000 publications
More than 110,000 topics
More than 75,000 authors
Published in the repository
  • How to publish
  • Definitions
  • Copyright
  • Frequent questions
Documents
  • Dating Guide
  • Thesis authorization
  • Document authorization
  • How to prepare a thesis (PDF)
Services
  • Digital library
  • Chilean academic journals portal
  • Latin American Repository Network
  • Latin American theses
  • Chilean theses
Dirección de Servicios de Información y Bibliotecas (SISIB)
Universidad de Chile

© 2020 DSpace
  • Access my account