6-Bromoflavone, a High Affinity Ligand for the Central Benzodiazepine Receptors Is a Member of a Family of Active Flavonoids
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6-Bromoflavone, a High Affinity Ligand for the Central Benzodiazepine Receptors Is a Member of a Family of Active Flavonoids
Abstract
6-Bromoflavone, obtained by bromination of flavanone, binds to central benzodiazepine receptors witb a
Ki =70 nM and has a clear anxiolytic activity in mice, at 0.5 mgJkg, i.p. A survey of tbe structure/affinity relationship
for tbose receptors in a series of natural and syntbetic flavonoids is presented.
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This work has been supported by grants from Consejo Nacional de Investigaciones Científícas y Técnicas (Argentina),
Universidad de Buenos Aires (Argentina), IFS (Sweden), OAS (Washington, DC) and Fundación Antorchas (Argentina).
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol. 223, p. 384-389, Article nº 0903, 1996.
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