About
Contact
Help
Sending publications
How to publish
Advanced Search
View Item 
  •   Home
  • Facultad de Ciencias
  • Artículos de revistas
  • View Item
  •   Home
  • Facultad de Ciencias
  • Artículos de revistas
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse byCommunities and CollectionsDateAuthorsTitlesSubjectsThis CollectionDateAuthorsTitlesSubjects

My Account

Login to my accountRegister
Biblioteca Digital - Universidad de Chile
Revistas Chilenas
Repositorios Latinoamericanos
Tesis LatinoAmericanas
Tesis chilenas
Related linksRegistry of Open Access RepositoriesOpenDOARGoogle scholarCOREBASE
My Account
Login to my accountRegister

Monoamine Oxidase Inhibitory Properties of Some Methoxylated and Alkylthio Amphetamine Derivatives STRUCTURE-ACTIVITY RELA TIONSHIPS

Artículo
Thumbnail
Open/Download
IconScorza_Ma_Cecilia.pdf (803.2Kb)
Publication date
1997
Metadata
Show full item record
Cómo citar
Scorza, Ma. Cecilia
Cómo citar
Monoamine Oxidase Inhibitory Properties of Some Methoxylated and Alkylthio Amphetamine Derivatives STRUCTURE-ACTIVITY RELA TIONSHIPS
.
Copiar
Cerrar

Author
  • Scorza, Ma. Cecilia;
  • Carrau, Cecilia;
  • Silveira, Rodolfo;
  • Zapata-Torres, Gerald;
  • Cassels Niven, Bruce;
  • Reyes Parada, Miguel;
Abstract
The monoamine oxidase (MAO) inhibitory propenies of a series of amphetamine derivatives with difTerent substituents at or around rhe para position of the aromaric ring were evaluateJ. i¡, in viero stuJies in which a crude rar brain mirochllndrial suspension was used as rhe source of MAO, several compounds showed a srrong (ICS0 in rhe submicromolar range), selecrive, reversible, time-independenr, and concenrrarion-related inhibition of MAO-A. After i.p. injection, the compounds induced an inerease of serotonin and a decrease of j-hydroxyindoleacetic acid in the raphe nuclei and hippocampus, confinning rhe in virro results. The analysis of structure-activity relationships indicates rhat: molecules with amphetamine-Iike structure and different substitutions nn the aromaric ring are potentially MAO-A inhibitors; substituents at different positions of the aromatic ring moditY the porency but have litde inf1uence "n the selectiviry; substituents at rhe para position sllch as ,lmino, alkoxyl. halogens. or alkylthio produce a significant increase in rhe acrivity; the para-substituent musr be an e1ectron Jonor; hulky ~roups next to rhe para subsriruent Icad ro a Jecrease in the actÍ\'ityi ,ubstiruents loearcd ar posirions more Jistant ,m rhe aromaric ring havc less intluence anJ, even when the subsriruent is '1 halogen (CI, Br), an increase in rhe acrivity "f rhe cllmpound is llbtained. Final!y, rhe MAO-A inhibirory properties of some of rhe compounJs evaluareJ are Jiscussed in relation to: (a) potential antidepressant acri\"Íry, and (b) their reponed hallllcinogenic, neurotoxic, nr anxiolyric effecrs.
Patrocinador
This work was supported in par by CONICYT (Uruguay) Grants 94/038 and 96/2005 (Fondo Clemente Estable), and Latin American Work on Natural Bioactive Compounds (LANBlO) , PEDEClBA (Uruguay), and FONDECYT (Chile) Granr 89/915.
Identifier
URI: https://repositorio.uchile.cl/handle/2250/119584
ISSN: 0006-2952
Quote Item
Biochemical Pharmacology, Vol. 54, pp. 1361-1369, 1997
Collections
  • Artículos de revistas
xmlui.footer.title
31 participating institutions
More than 73,000 publications
More than 110,000 topics
More than 75,000 authors
Published in the repository
  • How to publish
  • Definitions
  • Copyright
  • Frequent questions
Documents
  • Dating Guide
  • Thesis authorization
  • Document authorization
  • How to prepare a thesis (PDF)
Services
  • Digital library
  • Chilean academic journals portal
  • Latin American Repository Network
  • Latin American theses
  • Chilean theses
Dirección de Servicios de Información y Bibliotecas (SISIB)
Universidad de Chile

© 2020 DSpace
  • Access my account