Electrochemical oxidation of methylenedioxy amphetamines
Four amphetamine derivatives bearing a methylenedioxy group at positions 3 and 4 of the benzene ring and differing in their substitution at C(6) were studied by differential pulse voltammetry in aqueous media. These experiments showed a single oxidation peak for the C(6)-H, -Br and -CI compounds, while the C(6)-N02 analogue was not oxidized. The oxidation peak is interpreted as due to the removal of one eleetron from the aromatic eleetrophore with formation of a radical cation stabilized by the dioxole ring. The linear relationship between the peak current and the concentration of the derivatives is appropriate for development of a quantitative method for their determination. pK' values were determined using both eleetrochemical and spectrophotometric methods.
This work was supported in part by FONDECYT grants N" 915-89, 1110-92 and DTI Universidad de Chile grant N° 3121-9223.
Quote ItemTalanta, Vol. 40, No. 9, pp. 1379-1384, 1993