Synthesis of conformationally restricted N-{4-[4-(4,7-Dimethoxy-Benzo[b]Thiophene-2-Carbonyl)-1-Piperazinyl]-Phenyl}-Arylcarboxamides potential ligands with 5-HT1A binding affinity

Abstract

New benzothiophene arylpiperazine derivatives 7 (a-1) were synthesized as potential serotoninergic agents with 5-HT1A receptor affinity. Preparation of the derivatives was performed by reaction of 1-(4-aminophenyl)-4-[(4,7-dimethoxy-1-benzothien-2-yl)carbonyl] piperazine (6) with a series of substituted aroyl chlorides.