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Effects of 4,4-dimethyl-5,8-dihydroxynaphtalene-1-one and 4,4-dimethyl-5,8-dihydroxytetralone derivatives on tumor cell respiration

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2002-09
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Araya Maturana, Ramiro
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Effects of 4,4-dimethyl-5,8-dihydroxynaphtalene-1-one and 4,4-dimethyl-5,8-dihydroxytetralone derivatives on tumor cell respiration
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Author
  • Araya Maturana, Ramiro;
  • Delgado Castro, Tomás;
  • Gárate, M.;
  • Ferreira Parker, Jorge;
  • Pavani, M.;
  • Pessoa Mahana, Hernán;
  • Cassels Niven, Bruce;
Abstract
A set of structurally related compounds incorporating a carbonyl group in the ortho position with regard to a phenol function were tested against the TA3 mouse carcinoma cell line and its multidrug-resistant variant TA3-MTX-R, The series consists of 2'-hydroxyacetophenone. 4'-hydroxyacetophenone 2',5'-dihydroxyacetophenone, 4-acetyl-3,3-dimethyl-5-hydroxy-2-morpholino-2,3-dihydrobenzobfuran, five 4,4-dimethy-5,8-dioxygenated naphtalene-l-ones and three 4.4-dimethyl-5,8-dioxygenated tetralones. A tentative structure-activity relationship was found for this family of substances, suggesting that a coplanar ortho-carbonyl-1,4-hydroquinone motif is able to cause inhibition of cellular respiration.
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URI: https://repositorio.uchile.cl/handle/2250/120941
ISSN: 0968-0896
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BIOORGANIC & MEDICINAL CHEMISTRY 10(9): 3057-3060
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