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Extracellular Trypanosoma cruzi calreticulin in the host-parasite interplay

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2011-03
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Ramírez Toloza, Galia
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Extracellular Trypanosoma cruzi calreticulin in the host-parasite interplay
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Author
  • Ramírez Toloza, Galia;
  • Valck, Carolina;
  • Ferreira, Viviana P.;
  • López, Nandy;
  • Ferreira Vigouroux, Luis Arturo;
Abstract
Calreticulin (CRT) from vertebrates is a calcium-binding protein present mainly in the endoplasmic reticulum (ER). There, it directs the conformation of proteins and controls calcium levels. This review will focus on several extracellular roles of Trypanosoma cruzi CRT (TcCRT) in relation to its capacity to inhibit the complement system, mediate parasite infectivity, interfere with angiogenesis and, as a possible consequence, with tumor growth. The TcCRT antiangiogenic effect parallels with the capacity of T. cruzi infection to inhibit tumor development in vivo. Thus, the TcCRT, complement, and endothelial cell interactions seem to be an evolutionary adaptation to promote prolonged parasite-host relationships.
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Artículo de publicación ISI
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"Proyecto de Anillos do Investigation Asociativa" ACT 112 CONICYT, CHILE FONDECYT, CHILE 1095095
Identifier
URI: https://repositorio.uchile.cl/handle/2250/128923
DOI: DOI: 10.1016/j.pt.2010.12.007
ISSN: 1471-4922
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TRENDS IN PARASITOLOGY Volume: 27 Issue: 3 Pages: 115-122 Published: MAR 2011
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