Browsing by Subject "Cell migration"

Now showing items 1-14 of 14

    • A novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion 
      Díaz, Jorge; Mendoza, Pablo; Silva, Patricio; Quest, Andrew F. G.; Torres, Vicente A. (Landes Bioscience, 2014)
      © Jorge Díaz, Pablo endoza, Patricio Silva, Andrew FG Quest, and Vicente A Torres. The small GTPase Rab5 has been frequently studied in the context of intracellular trafficking, but evidence obtained more recently has ...
    • alpha (V) beta (3) Integrin regulates astrocyte reactivity 
      Lagos Cabre, Raúl; Álvarez, Álvaro; Kong, Milene; Burgos Bravo, Francesca; Cárdenas, Areli; Rojas Mancilla, Edgardo; Pérez Núñez, Ramón Daniel; Herrera Molina, Rodrigo; Rojas, Fabiola; Schneider, Pascal; Herrera-Marschitz Muller, Mario; Quest, Andrew F. G.; van Zundert, Brigitte; Leyton Campos, Lisette (BIOMED Central Ltd., 2017)
      Background: Neuroinflammation involves cytokine release, astrocyte reactivity and migration. Neuronal Thy-1 promotes DITNC1 astrocyte migration by engaging alpha(V)beta(3) Integrin and Syndecan-4. Primary astrocytes express ...
    • Cell migration: From tissue culture to embryos 
      Reig, Germán; Pulgar, Eduardo; Concha, Miguel L. (Company of Biologists Ltd, 2014)
      Cell migration is a fundamental process that occurs during embryo development. Classic studies using in vitro culture systems have been instrumental in dissecting the principles of cell motility and highlighting how cells ...
    • Emerging roles of the endoplasmic reticulum associated unfolded protein response in cancer cell migration ... 
      Limia, Celia Maria; Sauzay, Chloé; Urra, Hery; Hetz Flores, Claudio; Chevet, Eric; Avril, Tony (MDPI AG, 2019)
      Endoplasmic reticulum (ER) proteostasis is often altered in tumor cells due to intrinsic (oncogene expression, aneuploidy) and extrinsic (environmental) challenges. ER stress triggers the activation of an adaptive response ...
    • Focal Adhesion Dynamics Are Altered in Schizophrenia 
      Fan, Yongjun; Abrahamsen, Greger; Mills, Richard; Calderón, Claudia C.; Tee, Jing Yang; Leyton Campos, Lisette; Murrell, Wayne; Cooper White, Justin; McGrath, John J.; Mackay Sim, Alan (Society of Biological Psychiatry, 2013)
      Background: Evidence from genetic association studies implicate genes involved in neural migration associated with schizophrenia risk. Neural stem/progenitor cell cultures (neurosphere-derived cells) from olfactory mucosa ...
    • Integrin-mediated transactivation of P2X7R via hemichannel-dependent ATP release stimulates astrocyte migration 
      Álvarez, Álvaro; Lagos Cabré, Raúl; Kong, Milene; Cárdenas, Areli; Burgos Bravo, Francesca; Schneider, Pascal; Quest, Andrew F. G.; Leyton Campos, Lisette (Elsevier, 2016)
      Our previous reports indicate that ligand-induced alpha(v)beta(3) integrin and Syndecan-4 engagement increases focal adhesion formation and migration of astrocytes. Additionally, ligated integrins trigger ATP release through ...
    • Intracellular ca2+ increases and connexin 43 hemichannel opening are necessary but not sufficient for ... 
      Lagos Cabré, Raúl; Brenet, Marianne; Díaz, Jorge; Pérez, Ramón D.; Pérez, Leonardo A.; Herrera Molina, Rodrigo; Quest, Andrew F. G.; Leyton Campos, Lisette (MDPI AG, 2018)
      © 2018 by the authors. Licensee MDPI, Basel, Switzerland. Under pro-inflammatory conditions, astrocytes become reactive and acquire a migratory phenotype. Our results show that hemichannels formed by connexin 43 (Cx43) ...
    • K+ Channel Tetramerization Domain 5 (KCTD5) Protein Regulates Cell Migration, Focal Adhesion Dynamics and ... 
      Canales, Jimena; Cruz, Pablo; Villacura Díaz, Nicolás Esteban; Riquelme, Denise; Leiva Salcedo, Elias; Cerda Arancibia, Óscar (MDPI, 2020)
      Cell migration is critical for several physiological and pathophysiological processes. It depends on the coordinated action of kinases, phosphatases, Rho-GTPases proteins, and Ca2+ signaling. Interestingly, ubiquitination ...
    • KCTD5, a novel TRPM4-regulatory protein required for cell migration as a new predictor for breast cancer prognosis 
      Rivas, José; Díaz, Nicolás; Silva, Ian; Morales, Dana; Lavanderos, Boris; Álvarez, Alhejandra; Saldías Maulén, María Paz; Pulgar Pulgar, Eduardo; Cruz Núñez, Pablo; Maureira, Diego; Flores Utreras, Guillermo; Colombo Flores, Alicia; Blanco, Constanza; Contreras Muñoz, Héctor; Jaña, Fabián; Gallegos Méndez, Iván; Concha Nordemann, Miguel; Vergara Jaque, Ariela; Poblete, Horacio; González, Wendy; Varela Lekanda, Diego; Trimmer, James; Cáceres Lluch, Mónica Andrea; Cerda Arancibia, Óscar (Wiley, 2020)
      Transient receptor potential melastatin 4 (TRPM4) is a Ca2+-activated nonselective cationic channel that regulates cell migration and contractility. Increased TRPM4 expression has been related to pathologies, in which ...
    • Mutual influences between the main olfactory and vomeronasal systems in development and evolution 
      Suárez, Rodrigo; García-González, Diego; de Castro, Fernando (2012)
      The sense of smell plays a crucial role in the sensory world of animals. Two chemosensory systems have been traditionally thought to play independent roles in mammalian olfaction. According to this, the main olfactory ...
    • Slit/robo signaling regulates multiple stages of the development of the drosophila motion detection system 
      Guzmán Palma, Pablo; Contreras, Esteban G.; Mora, Natalia; Smith, Macarena; González Ramírez, M. Constanza; Campusano, Jorge M.; Sierralta Jara, Jimena Alejandra; Hassan, Bassem A.; Oliva, Carlos (Frontiers Media, 2021)
      Neurogenesis is achieved through a sequence of steps that include specification and differentiation of progenitors into mature neurons. Frequently, precursors migrate to distinct positions before terminal differentiation. ...
    • The Netrin-4/Neogenin-1 axis promotes neuroblastoma cell survival and migration 
      Villanueva, Andrea A.; Falcón, Paulina; Espinoza, Natalie; Solano, R. Luis; Milla, Luis A.; Hernandez-SanMiguel, Esther; Torres, Vicente A.; Sanchez-Gomez, Pilar; Palma, Verónica (Impact Journals LLC, 2017)
      Neogenin-1 (NEO1) is a transmembrane receptor involved in axonal guidance, angiogenesis, neuronal cell migration and cell death, during both embryonic development and adult homeostasis. It has been described as a dependence ...
    • The Parotoid Gland Secretion from Peruvian Toad Rhinella horribilis (Wiegmann, 1833): Chemical Composition ... 
      Schmeda Hirschmann, Guillermo; Andrade, Jean Paulo de; Soto Vásquez, Marilu Roxana; Alvarado García, Paul Alan Arkin; Palominos, Charlotte; Fuentes Retamal, Sebastián; Mellado, Mathias; Correa, Pablo; Urra Faúndez, Félix (MDPI, 2020)
      Since Rhinella sp. toads produce bioactive substances, some species have been used in traditional medicine and magical practices by ancient cultures in Peru. During several decades, the Rhinella horribilis toad was confused ...
    • Thy-1-mediated cell-cell contact induces astrocyte migration through the engagement of αVβ3 integrin and syndecan-4 
      Kong, Milene; Muñoz, Nicolás; Valdivia, Alejandra; Alvarez, Alvaro; Herrera Molina, Rodrigo; Cárdenas, Areli; Schneider, Pascal; Burridge, Keith; Quest, Andrew F. G.; Leyton Campos, Lisette (2013)
      Cell adhesion to the extracellular matrix proteins occurs through interactions with integrins that bind to Arg-Gly-Asp (RGD) tripeptides, and syndecan-4, which recognizes the heparin-binding domain of other proteins. Both ...