Genetic polymorphisms in the immune response: A focus on kidney transplantation
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The modulation of the immune system following solid organ transplantation has made considerable progress with new immunosuppressive regimens and has considerably improved rejections rates. The improvement in long-term allograft survival is, however, modest. A complex network of cytokines, chemokines, adhesion, activation and co-stimulatory molecules are the frontline contributors to allograft rejection, which in turn determines the evolution of graft function and its long-term survival. Polymorphisms in these genes influence protein levels and presumably their signaling effects. In this review, we present a relevant panel of candidate genes related to the immune system in the context of solid organ transplantation; we discuss the most convincing reports of genetic associations with outcomes in renal transplantation and highlight the most promising loci among the vast body of literature.
Artículo de publicación ISI
ISSN: DOI: 10.1016/j.clinbiochem.2015.07.016
Quote ItemClinical Biochemistry 49 (2016) 363–376
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