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Genetic polymorphisms in the immune response: A focus on kidney transplantation

Authordc.contributor.authorStojanova, Jana 
Authordc.contributor.authorPouche, Lucie 
Authordc.contributor.authorPicard, Nicolas 
Cita de ítemdc.identifier.citationClinical Biochemistry 49 (2016) 363–376en_US
Identifierdc.identifier.issnDOI: 10.1016/j.clinbiochem.2015.07.016
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractThe modulation of the immune system following solid organ transplantation has made considerable progress with new immunosuppressive regimens and has considerably improved rejections rates. The improvement in long-term allograft survival is, however, modest. A complex network of cytokines, chemokines, adhesion, activation and co-stimulatory molecules are the frontline contributors to allograft rejection, which in turn determines the evolution of graft function and its long-term survival. Polymorphisms in these genes influence protein levels and presumably their signaling effects. In this review, we present a relevant panel of candidate genes related to the immune system in the context of solid organ transplantation; we discuss the most convincing reports of genetic associations with outcomes in renal transplantation and highlight the most promising loci among the vast body of literature.en_US
Type of licensedc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
Link to Licensedc.rights.uri*
Keywordsdc.subjectImmune responseen_US
Keywordsdc.subjectImmunosuppressive therapyen_US
Keywordsdc.subjectGene polymorphismen_US
Títulodc.titleGenetic polymorphisms in the immune response: A focus on kidney transplantationen_US
Document typedc.typeArtículo de revistaen_US

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Atribución-NoComercial-SinDerivadas 3.0 Chile
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 Chile