Sodium pathway markers in normal and kindled frog brains
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1986Metadata
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Moneta, María Eugenia
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Sodium pathway markers in normal and kindled frog brains
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Abstract
The present report evaluates Na,K-ATPase activity as well as Na channel levels in the frog telencepha-
Ion after kindling, i.e. the acquisition of an epileptic focus through localized low-voltage electrical stimulation
of one hemisphere. K-dependent phosphatase activity and binding of tritiated ouabain were
measured, revealing no change in Na,K-ATPase activity 14 h after the last seizure. Na channels were
measured by binding assays using a tritiated ethylenediamine tetrodotoxin derivative. Na channels were
reduced in kindled brain as compared to controls.
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Neuroscience Letters, 65 (1986) 331-335
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