Now showing items 27910-27929 of 92550

    • Urrutia Laubreaux, Daniel; Rodríguez Guerra, José Manuel (Universidad de Chile, 2000)
      1. Objetivo del trabajo: nuestra tesis apunta a realizar un diagnóstico de la situación de la droga en Chile, revisar la actual legislación y proponer una reforma acorde con los principios generales de un estado democrático ...
    • Givovich Díaz, Felipe Arturo (Universidad de Chile, 2002)
      En Chile durante el decenio 1990-2000 el gasto público en educación como porcentaje del PIB se ha incrementado en un 1.7 puntos porcentuales1. Sin embargo, dicho aumento no ha ido acompañado de una mejora significativa ...
    • Larenas González, María Isabel (Universidad de Chile, 2005-03-18)
      El presente artículo examina como habilidades no-cognitivas de los estudiantes secundarios chilenos pueden afectar sus logros educacionales. Tres modelos econométricos son utilizados para este propósito. En cada uno de ...
    • Bello Dragicevic, Josefina (Universidad de Chile, 2013)
      En el presente trabajo se pretende evaluar el impacto del consumo de drogas lícitas e ilícitas en el bienestar del individuo. Específicamente se mide el efecto del abuso de drogas en el salario y en la tasa de participación ...
    • De Gregorio, Cristián; Delgado Arriagada, Ricardo; Ibacache, Andrés; Sierralta Jara, Jimena; Couve Correa, Andrés (Company of Biologists Ltd., 2017)
      Hereditary spastic paraplegias (HSPs) are characterized by spasticity and weakness of the lower limbs, resulting from length-dependent axonopathy of the corticospinal tracts. In humans, the HSP-related atlastin genes ...
    • Glavic Maurer, Álvaro; Molnar, Cristina; Cotoras, Darko; Celis, José F. de (ELSEVIER SCIENCE BV, 2008-11-28)
      Cell division rates and apoptosis sculpt the growing organs, and its regulation implements the developmental programmes that define organ size and shape. The balance between oncogenes and tumour suppressors modulate the ...
    • Rojas Benítez, Diego; Ibar, Consuelo; Glavic Maurer, Álvaro (Landes Bioscience, 2013)
      The TOR signaling pathway is crucial in the translation of nutritional inputs into the protein synthesis machinery regulation, allowing animal growth. We recently identified the Bud32 (yeast)/PRPK (human) ortholog in ...
    • Galagovskya, Diego; Katz, Maximiliano J.; Acevedo, Julieta M.; Sorianello, Eleonora; Glavic Maurer, Álvaro; Wappner, Pablo (2014)
      Mammalian insulin-degrading enzyme (IDE) cleaves insulin, among other peptidic substrates, but its function in insulin signaling is elusive. We use the Drosophila system to define the function of IDE in the regulation of ...
    • Ibar Valenzuela, María Consuelo; Glavic Maurer, Álvaro (Elsevier, 2017-04)
      Golgi complex inheritance and its relationship with the cell cycle are central in cell biology. Golgi matrix proteins, known as golgins, are one of the components that underlie the shape and functionality of this organelle. ...
    • Ibar, Consuelo; Cataldo, Vicente F.; Vásquez Doorman, Constanza; Olguín Aguilera, Patricio; Glavic Maurer, Álvaro (2013)
      Cell growth and proliferation are pivotal for final organ and body size definition. p53-related protein kinase (Bud32/PRPK) has been identified as a protein involved in proliferation through its effects on transcription ...
    • Beltramí, Marcial; Medina Muñoz, María Cristina; Arce, David; Godoy Herrera, Raúl (Springer, 2010)
      We investigated pupa distributions of D. simulans, D. buzzatii, D. melanogaster, D. immigrans and D. hydei on a number of natural breeding sites. Pupae of all five species showed aggregated distributions, which prompted ...
    • Zepeda Iriarte, Ramiro; Kuzmicic, Jovan; Parra Ortiz, Valentina; Troncoso Cotal, Rodrigo; Pennanen, Christian; Riquelme, Jaime A.; Pedrozo Cibils, Zully; Chiong Lay, Mario; Sánchez, Gina; Lavandero González, Sergio (Lippincott Williams and Wilkins, 2014)
      Mitochondria are key organelles for ATP production in cardiomyocytes, which is regulated by processes of fission and fusion. We hypothesized that the mitochondria fusion protein dynamin-related protein 1 (Drp1) inhibition, ...
    • Rodríguez T., Jorge; Valdés, C. Macarena; Fernández, Ana María; Dalbosco R., Daniela; Hoffman S., Marianela; Flores O., María Fernanda; Lee A., María Javiera; Ramírez F., Rafael; Ramírez P., Enrica; Pruzzo, Matías (2011)
      The objective of this study is to compare the declared licit and illicit drug consumption, between paired methodology (MP) and self assessed questionnaire (CAR). We suggest that understatement of illicit drug use will be ...
    • Valenzuela, Romina; Torres, Juan P.; Salas, Carolina; Sandoval Gajardo, Iván Elías; Palma, Julia; Catalán, Paula; Santolaya de Pablo, María Elena; Morales, Jorge (Sociedad Chilena de Infectologia, 2017)
      © 2017, Sociedad Chilena de Infectologia. All rights reserved.Background: Drug interactions (DI) in patients receiving hematopoietic stem cell transplantation (HSCT) are common and clinically significant, highlighting: ...
    • Arellano, Javier; Vargas, Pablo; Martínez, Claudia; Chahuan, Marco; Corredoira, Yamile (Sociedad Medica de Santiago, 2019)
      Drug rash with eosinophilia and systemic symptoms or DRESS Syndrome is a rare, serious and potentially fatal adverse drug reaction. It is characterized by widespread morbilliform and edematous skin lesions, associated with ...
    • Mercado Guerra, María Gabriela; Hetz Flores, Claudio (Oxford University Press, 2017-06)
    • Núñez Vergara, Luis; Yudelevich, J.; Squella Serrano, Juan; Speisky Cosoy, Hernán (Oxford University Press, 1991)
      Acetaldehyde, at concentrations occurring in vivo was found to avidly react in vitro with several clinically relevant drugs. The greatest reactivity was observed for the hydrazine and hydrazide-containing drugs, hydralazine ...
    • Chou, Wai-Houng; Galaz, Ariel; Jara, Miguel O.; Gamboa, Alexander; Morales Montecinos, Javier (MDPI, 2020)
      The aim of the study was to develop a novel buccal dosage form to transport rhodamine 123 and human insulin as models for poorly water-soluble and biological drugs, using lipid-core micelles (LCMs)-loaded mucoadhesive ...
    • Hernández,; Parraguez,; Wolff Fernández, Carlos; Armas-Merino, Rodolfo (1992)
      Life threatening crisis may accompany some varieties of porphyria like the acute intermittent form, coproporphyria, porphyria variegata and that associated to deficiency of porphobilinogen synthetase. Drugs are commonly ...
    • Fungo, Marta Stella Maris; Vega, Elena María (Sociedad Argentina de Pediatria, 2013)
      Introduction: The objective was to analyze the number of drugs dispensed by the Pharmacy Department to the Neonatology Division, to find out if the use of these drugs is described on the package insert approved by the ...