Browsing by Title Facultad de Ciencias Químicas y Farmacéuticas
Now showing items 2802-2821 of 4849
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(Universidad de Chile, 2007)La enfermedad de Chagas constituye uno de los principales problemas en salud pública en América Latina. Las drogas disponibles en la actualidad para el tratamiento, Nifurtimox y Benznidazol no presentan una respuesta ...
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(Universidad de Chile, 2020)El metabolismo mitocondrial ha emergido como un blanco importante para las terapias contra el cáncer. Para este propósito, se conjugó el ácido gentísico al catión trifenilfosfonio (GA-TPP+C10) con el fin de provocar su ...
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(Universidad de Chile, 2011)
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(Universidad de ChileCyberDocs, 2010)El alcoholismo está determinado por factores genéticos y medioambientales. El factor genético principal corresponde a los genes que codifican las enzimas que metabolizan el alcohol. El metabolismo hepático del etanol ...
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(Universidad de Chile, 2017)La depresión es un trastorno psiquiátrico muy prevalente en Chile y el mundo. Sus bases moleculares son prácticamente desconocidas, por lo que los tratamientos farmacológicos no han logrado ser del todo efectivos. En la ...
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(1986)Short or long term alloxan diabetes produced activation of oestrone and morphine glucuronidation and inhibition of p-nitrophenol glucuronidation in rat liver microsomes. Insulin treatment restored decreased glucuronyltransferase ...
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(2011)Autophagic responses are coupled to the activation of the inhibitor of NF-κB kinase (IKK). Here, we report that the essential autophagy mediator Beclin 1 and TGFβ-activated kinase 1 (TAK1)-binding proteins 2 and 3 (TAB2 ...
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(Bentham Science Publishers, 2020)The beta-amyloid peptide (1-42) is a molecule capable of aggregating into neurotoxic structures that have been implicated as potential etiological factors of Alzheimer's Disease. The aim of this study was to evaluate the ...
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(Amer Assoc Advancement Science, 2016)Altering chromatin structure through histone posttranslational modifications has emerged as a key driver of transcriptional responses in cells. Modulation of these transcriptional responses by pharmacological inhibition ...
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(ELSEVIER, 2006-12-01)H2O2 inactivation of particular GST isoforms has been reported, with no information regarding the overall effect of other ROS on cytosolic GST activity. The present work describes the inactivation of total cytosolic GST ...
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(EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2001-11)We investigated the effects of alpha1-antitrypsine Portland variant (alpha1-PDX) and decanoylRVKRchloromethylketone (decRVKRcmk) on HIV-2(ROD) replication in the Jurkat lymphoblastoid cell line. To this end, cells were ...
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(Frontiers Media, 2020)Lithraea caustica (Molina) Hook. and Arn. (Anacardiaceae), common name Litre, is an evergreen endemic plant used in the Mapuche Chilean folk medicine. The stem juice of L. caustica mixed with Rubus ulmifolius (blackberry) ...
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(PERGAMON-ELSEVIER SCIENCE LTD, 2005-02-15)Elevated serum tumor necrosis factor alpha JNF-alpha) levels predict mortality in patients with alcoholic liver disease. Administration of anti-TNF-alpha antibodies, obliteration of Kupffer cells or gut sterilization protect ...
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(PERGAMON-ELSEVIER SCIENCE LTD, 1994-11-16)The effects of nordihydroguaiaretic acid (NDGA), best known as an inhibitor of lipoxygenase activities, on the culture growth, oxygen consumption, ATP level, viability, and redox state of some electron carriers of intact ...
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(ELSEVIER SCIENCE BV, 2002-09)The effects of some imine and amine derivatives of vanillin on the respiration rate of mouse mammary adenocarcinoma TA3 line, its multiresistant variant TA3-MTX-R line and mouse hepatocytes, together with their respective ...
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(Springer New York LLC, 2017)© 2016, American Association of Pharmaceutical Scientists. Peptides and proteins represent a promissory group of molecules used by the pharmaceutical industry for drug therapy with great potential for development. However, ...
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(Universidad de Chile, 2024)En la presente memoria de título, se reportan los resultados de dos estrategias electroquímicas de modificación de electrodos: una denominada Botton-up y la otra “compósito”, aplicadas a superficies de electrodos de carbono ...
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(ENDOCRINE SOC, 2010-10)Intracellular calcium levels ([Ca2+](i)) and glucose uptake are central to cardiomyocyte physiology, yet connections between them have not been studied. We investigated whether insulin regulates [Ca2+](i) in cultured ...
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The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1 (NATURE PUBLISHING GROUP, 2009-07)The inositol 1,4,5-trisphosphate receptor (IP3R) is a major regulator of apoptotic signaling. Through interactions with members of the Bcl-2 family of proteins, it drives calcium (Ca2+) transients from the endoplasmic ...
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(LANDES BIOSCIENCE, 2007-07)The second messenger myo-inositol-1,4,5-trisphosphate (IP3) acts on the IP3 receptor (IP3R), an IP3-activated Ca2+ channel of the endoplasmic reticulum (ER). The IP3R agonist IP3 inhibits starvation-induced autophagy. The ...