About
Contact
Help
Sending publications
How to publish
Advanced Search
View Item 
  •   Home
  • Facultad de Medicina
  • Artículos de revistas
  • View Item
  •   Home
  • Facultad de Medicina
  • Artículos de revistas
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse byCommunities and CollectionsDateAuthorsTitlesSubjectsThis CollectionDateAuthorsTitlesSubjects

My Account

Login to my accountRegister
Biblioteca Digital - Universidad de Chile
Revistas Chilenas
Repositorios Latinoamericanos
Tesis LatinoAmericanas
Tesis chilenas
Related linksRegistry of Open Access RepositoriesOpenDOARGoogle scholarCOREBASE
My Account
Login to my accountRegister

Thyroid hormone-induced oxidative stress in rodents and humans: A comparative view and relation to redox regulation of gene expression

Artículo
Thumbnail
Open/Download
IconFernandez_Virginia.pdf (438.4Kb)
Publication date
2006-04
Metadata
Show full item record
Cómo citar
Fernández Arancibia, Virginia
Cómo citar
Thyroid hormone-induced oxidative stress in rodents and humans: A comparative view and relation to redox regulation of gene expression
.
Copiar
Cerrar

Author
  • Fernández Arancibia, Virginia;
  • Tapia Opazo, Gladys;
  • Varela, Patricia;
  • Romanque Ulloa, Pamela;
  • Cartier Ugarte, Denise;
  • Videla Cabrera, Luis;
Abstract
Thyroid hormone (3,3',5-triiodothyronine, T-3) exerts significant actions on energy metabolism, with mitochondria being the major target for its calorigenic. effects. Acceleration of O-2 consumption by T-3 leads to ail enhanced generation of reactive oxygen and nitrogen species in target tissues, with a higher consumption of cellular antioxidants and inactivation of antioxidant enzymes, thus inducing oxidative stress. This redox imbalance occurring in rodent liver and extrahepatic tissues with a calorigenic response, as well as in hyperthyroid patients, is further enhanced by an increased respiratory burst activity in Kupffer cells, which may activate redox-sensitive transcription factors such as NF-kappa B thus up-regulating gene expression. T-3 elicits an 80-fold increase in the serum levels of tumor necrosis factor-alpha (TNF-alpha), which is abolished by pretreatment with the antioxidants alpha-tocopherol and N-acetylcysteine, the Kupffer-cell inactivator GdCl3, or an antisense oligonucleotide against TNF-alpha. In addition, T-3 treatment activates hepatic NF-kappa B, a response that is (i) inhibited by antioxidants and GdCl3 and (ii) accompanied by induced mRNA expression of the NF-kappa B-responsive genes for TNF-alpha and interleukin (IL)-10. T-3 also increases the hepatic levels of mRNA for IL-1 alpha and those of IL-1 alpha in serum. Up-regulation of liver iNOS expression is also achieved by T-3, through a cascade initiated by TNF-alpha and involving I kappa B-alpha phosphorylation and NF-kappa B activation. In conclusion, T-3-induced oxidative stress in the liver enhances the DNA-binding of NF-kappa B and the NF-kappa B-dependent expression of cytokines and iNOS by actions primarily exerted at the Kupffer cell level.
Identifier
URI: https://repositorio.uchile.cl/handle/2250/127731
ISSN: 1532-0456
Quote Item
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY Volume: 142 Issue: 3-4 Pages: 231-239 Published: MAR-APR 2006
Collections
  • Artículos de revistas
xmlui.footer.title
31 participating institutions
More than 73,000 publications
More than 110,000 topics
More than 75,000 authors
Published in the repository
  • How to publish
  • Definitions
  • Copyright
  • Frequent questions
Documents
  • Dating Guide
  • Thesis authorization
  • Document authorization
  • How to prepare a thesis (PDF)
Services
  • Digital library
  • Chilean academic journals portal
  • Latin American Repository Network
  • Latin American theses
  • Chilean theses
Dirección de Servicios de Información y Bibliotecas (SISIB)
Universidad de Chile

© 2020 DSpace
  • Access my account