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Insight into the Bioreductive Mode of Action of Antitrypanosomal 5-Nitrofuryl Containing Thiosemicarbazones

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2008
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Otero, Lucía
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Insight into the Bioreductive Mode of Action of Antitrypanosomal 5-Nitrofuryl Containing Thiosemicarbazones
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Author
  • Otero, Lucía;
  • Maya Arango, Juan;
  • Morello Casté, Antonio;
  • Rigol, C.;
  • Barriga, Germán;
  • Rodríguez, J.;
  • Folch, C.;
  • Norambuena, Ester;
  • González, M.;
  • Olea Azar, Claudio;
  • Cerecetto, Hugo;
  • Gambino, Dinorah;
Abstract
In order to get insight into the trypanocidal mechanism of action of a series of 5-nitrofuryl containing thiosemicarbazones some studies related to their bioreduction were performed. Electron spin resonance spectra of radicals generated in T. cruzi by compounds´ bioreduction were analyzed. Three different patterns of ESR signals were observed for the different assayed compounds. These results were in agreement with the changes in the T. cruzi-oxygen uptake promoted by these compounds. On the other hand, free-radical scavenger properties, measured as oxygen radical absorbance capacity (ORAC), did not seem to correlate with the trypanocidal activity.
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This research was partially supported by TWAS (research grant RG/CHE/LA 04-205), FONDECYT 1030949 and 1061072 grants, CONICYT AT-4040020 grant, PBCT/ CONICYT Anillo ACT 29, U. de Chile DID graduate grant PG-65. L.O. thanks RTPD and CSIC (Uruguay) for a scholarship.
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URI: https://repositorio.uchile.cl/handle/2250/128420
ISSN: 1573-4064
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Medicinal Chemistry, 2008, 4, 11-17
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