Now showing items 4101-4120 of 5194

    • Xie, Min; Morales, Cindy R.; Lavandero González, Sergio; Hill, Joseph A. (LIPPINCOTT WILLIAMS & WILKINS, 2011-05)
      Whereas we have known for some years of the participation of lysosomal mechanisms in heart disease, it is only recently that upstream mechanisms (autophagy) are being explored. The challenge for the future is to dissect ...
    • Bravo Méndez, Roberto; Vicencio Bustamante, José Miguel; Parra Ortíz, María Valentina; Troncoso, Rodrigo; Muñoz, Juan Pablo; Bui, Michael; Quiroga Lagos, Clara; Rodríguez Villarroel, Andrea Elizabeth; Verdejo, Hugo E.; Ferreira Parker, Jorge; Iglewski, Miriam; Chiong Lay, Mario; Simmen, Thomas; Zorzano, Antonio; Hill, Joseph A.; Rothermel, B. A.; Szabadkai, Gyorgy; Lavandero González, Sergio (COMPANY OF BIOLOGISTS LTD., 2011-07-15)
      Increasing evidence indicates that endoplasmic reticulum (ER) stress activates the adaptive unfolded protein response (UPR), but that beyond a certain degree of ER damage, this response triggers apoptotic pathways. The ...
    • Bollo Dragnic, Soledad; Núñez Vergara, Luis; Kang, Sunhee; Zhang, Liang; Boshoff, Helena I.; Barry, Clifton; Squella Serrano, Juan; Dowd, Cynthia S. (PERGAMON-ELSEVIER SCIENCE LTD, 2011-01-15)
      Nitroimidazole PA-824 is part of an exciting new class of compounds currently undergoing clinical evaluation as novel TB therapeutics. The recently elucidated mechanism of action of PA-824 involves reduction of the ...
    • Ocaranza, María Paz; Rivera, Paulina; Novoa, Ulises; Pinto, Melissa; González, Leticia; Chiong Lay, Mario; Lavandero González, Sergio; Jalil Milad, Jorge (LIPPINCOTT WILLIAMS & WILKINS, 2011-04)
      Background Angiotensin II (Ang II) levels depend on renin, angiotensin-converting enzyme (ACE), and on the homologous angiotensin-converting enzyme (ACE2). Increased ACE and Ang II levels are associated with higher Rho ...
    • Parra Ortíz, María Valentina; Verdejo, Hugo; Campo Sfeir, Andrea Estefanía del; Pennanen Saavedra, Christian; Kuzmicic, Jovan; Iglewski, Myriam; Hill, Joseph A.; Rothermel, B. A.; Lavandero González, Sergio (SPRINGER/PLENUM PUBLISHERS, 2011-02)
      Mitochondria are highly dynamic organelles, capable of undergoing constant fission and fusion events, forming networks. These dynamic events allow the transmission of chemical and physical messengers and the exchange of ...
    • Aránguiz Urroz, Pablo Daniel; Canales Urriola, Jimena Andrea; Copaja, Miguel; Troncoso Cotal, Rodrigo; Vicencio Bustamante, José Miguel; Carrillo Ballesteros, Constanza Carolina; Lara Peñaloza, Hernán; Lavandero González, Sergio; Díaz Araya, Guillermo (ELSEVIER SCIENCE BV, 2011-01)
      Autophagy is a physiological degradative process key to cell survival during nutrient deprivation, cell differentiation and development. It plays a major role in the turnover of damaged macromolecules and organelles, and ...
    • Alcaíno Olivares, Hernán Alejandro; Greig, Douglas; Castro Agüero, Pablo; Verdejo, Hugo; Mellado, Rose Marie; García Nannig, Lorena; Díaz Araya, Guillermo; Quiroga Lagos, Clara; Chiong Lay, Mario; Lavandero González, Sergio (SOC MEDICA SANTIAGO, 2011-04)
      Complications and mortality of heart failure are high, despite the availability of several forms of treatment. Uric acid, the end product of purine metabolism would actively participate in the pathophysiology of heart ...
    • Moscoso Cabello, Raúl Andrés; Carbajo, J.; López, M.; Núñez Vergara, Luis; Squella Serrano, Juan (ELSEVIER SCIENCE INC, 2011-02)
      We report that GCE modified with MWCNTs can be derivatized by the nitroaromatic drug nitrendipine (NTD) ((RS)-ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate) simply by dipping the electrode ...
    • García, R.; Erazo, Silvia; Cánepa, A.; Lemus Gutiérrez, Igor (Real Academia de Farmacia, 1990)
      Se ha llevado a cabo un estudio fitoquímico de las hojas de Escallonia illinita Presl. Escalloniaceae) una planta aromática nativa de Chile, usada en medicina popular para enfermedades hepáticas y conocida vulgarmente como ...
    • Cárcamo, J.; Lobos, S.; Merino, A.; Buckbinder, L.; Wienmann, R.; Natarajan, V.; Reinberg, D. (National Institute of Health, 1989)
      Almost every week, it seems, another character appears, expending the cast of DNA-binding proteins. Some of these proteins are destined for major roles, binding to DNA sequences a few hundred basepairs upstream of key ...
    • Quintana, Ana María; Rebolledo, Rosa; Jaña, Waldo; Masson Salaué, Lilia; Schmidt Hebbel, Hermann; Wittig Rovira, Emma; Zuccarelli, María T. (Sociedad Chilena de Nutrición, Bromatología y Tecnología, 1981)
      Organoleptic quality and nutritional value are important parameters in the evaluation of foodstuffs. Food entirely adequate from the nutritional point of view be rejected if is not acceptable because of colour, taste, ...
    • Puente Díaz, Luis; Pinto Muñoz, Claudia A.; Castro Montero, Eduardo; Cortés, Misael (Elsevier Ltd., 2011)
      The main objective of this work is to spread the physicochemical and nutritional characteristics of the Physalis peruviana L., fruit and the relation of their physiologically active components with beneficial effects on ...
    • Vicuña E., Rafael; Cori, Osvaldo (Elsevier Science, 1981)
    • Cornwell, E. (Real Academia Nacional de Farmacia, 2007)
      Un nuevo parámetro topográfico (Vc3) aplicado a la disciplina QSPR se utiliza para la reducción del número de variables independientes a una sola variable denominada Vc3. La reducción está basada en la relación de las ...
    • Schalscha B., Eduardo; Escudero, Paula; Ahumada Torres, Aída Inés de Lourdes (Universita degli Studi di Pisa, Istituto di Chimica Agraria, 1999)
      La movilidad y disponibilidad de micro elementos o trazas de metales pesados es una función de su contenido en el substrato y está determinada principalmente por las formas químicas en que se presente en aquel (KABATAPENDIAS, ...
    • Ahumada Torres, Aída Inés de Lourdes; Schalscha B., Eduardo (Universita degli Studi di Pisa, Istituto di Chimica Agraria, 1995)
      El riego con aguas servidas no tratadas, el depósito de lodos provenientes de plantas de tratamiento de aguas, el relleno sanitario y también el uso de ciertos fertilizantes, pueden contribuir a modificar la forma y cantidad ...
    • Vergara, I.; Schalscha B., Eduardo (Universita degli Studi di Pisa, Istituto di Chimica Agraria, 1992)
      Wasterwastes of municipal and industrial origin used to irrigate farmlands contain heavy metals which are sorbed on the surfaces of soil particles. Among those metals are cadmium (Cd) and copper(Cu). The degree to which ...
    • Steiner W., Jeannette; Mella C., Marcos; Polanco, R.; Ortega A., Ximena; Eyzaguirre, Jaime (Asociación Chilena de Microbiología, 1996)
      Las xilanasas son enzimas, producidas por hongos y bacterias que degradan el xilano de las hemicelulosas vegetales y tienen una importante aplicación en el bioblanqueamiento de la celulosa. A partir de compost, se ...
    • Schmidt Hebbel, Hermann (Santiago, Chile, Círculo de Estudios de Química y Farmacia, 1931)
      En los análisis bromatológicos de diferentes productos alimenticios, como chocolates y bizcochos de leche, mazapanes, pasteles y galletas a base de mantequilla, etc. se tropieza a menudo con la dificultad de reconocer, si ...
    • Zunino Venegas, Hugo; Peirano V., Pedro; Aguilera S., S. María; Escobar, I. (The Williams & Wilkins Co., 1972)
      When the maximum complexing ability (MCA) of water-soluble complexants of unknown molecular weight is known, it is possible to calculate the stability constants of metal complexes where these complexants participate (2,4,5). ...